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Title: Formulation for Tin-.sup.117m /diethylenetriaminepentaacetic acids

Abstract

The invention provides improved formulations of .sup.117m Sn (Sn.sup.4+) DTPA which allow higher doses of .sup.117m Sn (Sn.sup.4+) to be administered than were previously possible. Methods for making pharmaceutical compositions comprising .sup.117m Sn (Sn.sup.4+) DTPA in which the amount of unchelated DTPA is minimized are disclosed along with methods of using the improved formlulations, both for palliation of bone pain associated with cancer and for treatment of osseous tumors.

Inventors:
 [1];  [2]
+ Show Inventor Affiliations
  1. Setauket, NY
  2. Middle Island, NY
Issue Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
OSTI Identifier:
872770
Patent Number(s):
6004532
Assignee:
Brookhaven Science Associates (Upton, NY)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
formulation; tin-; 117m; diethylenetriaminepentaacetic; acids; provides; improved; formulations; dtpa; allow; doses; administered; previously; methods; pharmaceutical; compositions; comprising; amount; unchelated; minimized; disclosed; formlulations; palliation; bone; pain; associated; cancer; treatment; osseous; tumors; pharmaceutical compositions; bone pain; acetic acid; provides improved; compositions comprising; pharmaceutical composition; /424/999/600/

Citation Formats

Srivastava, Suresh C, and Meinken, George E. Formulation for Tin-.sup.117m /diethylenetriaminepentaacetic acids. United States: N. p., 1999. Web.
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Srivastava, Suresh C, & Meinken, George E. Formulation for Tin-.sup.117m /diethylenetriaminepentaacetic acids. United States.
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Srivastava, Suresh C, and Meinken, George E. Fri . "Formulation for Tin-.sup.117m /diethylenetriaminepentaacetic acids". United States. https://www.osti.gov/servlets/purl/872770.
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@article{osti_872770,
title = {Formulation for Tin-.sup.117m /diethylenetriaminepentaacetic acids},
author = {Srivastava, Suresh C and Meinken, George E},
abstractNote = {The invention provides improved formulations of .sup.117m Sn (Sn.sup.4+) DTPA which allow higher doses of .sup.117m Sn (Sn.sup.4+) to be administered than were previously possible. Methods for making pharmaceutical compositions comprising .sup.117m Sn (Sn.sup.4+) DTPA in which the amount of unchelated DTPA is minimized are disclosed along with methods of using the improved formlulations, both for palliation of bone pain associated with cancer and for treatment of osseous tumors.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}
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Works referenced in this record:

Improved specific activity of reactor produced 117mSn with the Szilard-Chalmers process
journal, September 1992

  • Mausner, L. F.; Mirzadeh, S.; Srivastava, S. C.
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 43, Issue 9, p. 1117-1122
  • https://doi.org/10.1016/0883-2889(92)90053-H

Cancer therapy using bone-seeking isotopes
journal, October 1996

Biodistribution of Sn-117m(4+)DTPA for palliative therapy of painful osseous metastases.
journal, January 1993

Tin-117m: Production, chemistry and evaluation as a bone-scanning agent
journal, June 1973

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