Open-top microfluidic devices and methods for simulating a function of a tissue
Abstract
A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber.
- Inventors:
- Issue Date:
- Research Org.:
- Harvard Univ., Cambridge, MA (United States)
- Sponsoring Org.:
- USDOE; Defense Advanced Research Projects Agency (DARPA)
- OSTI Identifier:
- 1986841
- Patent Number(s):
- 11505773
- Application Number:
- 15/781,078
- Assignee:
- President and Fellows of Harvard College (Cambridge, MA)
- DOE Contract Number:
- W911NF-12-2-0036
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 12/02/2016
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Varone, Antonio, Wen, Norman, Levner, Daniel, Novak, Richard, McPartlin, Lori, Ingber, Donald E., Choe, Youngjae, Leng, Lian, and Nguyen, Justin K. Open-top microfluidic devices and methods for simulating a function of a tissue. United States: N. p., 2022.
Web.
Varone, Antonio, Wen, Norman, Levner, Daniel, Novak, Richard, McPartlin, Lori, Ingber, Donald E., Choe, Youngjae, Leng, Lian, & Nguyen, Justin K. Open-top microfluidic devices and methods for simulating a function of a tissue. United States.
Varone, Antonio, Wen, Norman, Levner, Daniel, Novak, Richard, McPartlin, Lori, Ingber, Donald E., Choe, Youngjae, Leng, Lian, and Nguyen, Justin K. Tue .
"Open-top microfluidic devices and methods for simulating a function of a tissue". United States. https://www.osti.gov/servlets/purl/1986841.
@article{osti_1986841,
title = {Open-top microfluidic devices and methods for simulating a function of a tissue},
author = {Varone, Antonio and Wen, Norman and Levner, Daniel and Novak, Richard and McPartlin, Lori and Ingber, Donald E. and Choe, Youngjae and Leng, Lian and Nguyen, Justin K.},
abstractNote = {A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 22 00:00:00 EST 2022},
month = {Tue Nov 22 00:00:00 EST 2022}
}
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