Open-top microfluidic devices and methods for simulating a function of a tissue
Abstract
A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber.
- Inventors:
- Issue Date:
- Research Org.:
- Harvard Univ., Cambridge, MA (United States)
- Sponsoring Org.:
- USDOE; Defense Advanced Research Projects Agency (DARPA)
- OSTI Identifier:
- 1986841
- Patent Number(s):
- 11505773
- Application Number:
- 15/781,078
- Assignee:
- President and Fellows of Harvard College (Cambridge, MA)
- DOE Contract Number:
- W911NF-12-2-0036
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 12/02/2016
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Varone, Antonio, Wen, Norman, Levner, Daniel, Novak, Richard, McPartlin, Lori, Ingber, Donald E., Choe, Youngjae, Leng, Lian, and Nguyen, Justin K. Open-top microfluidic devices and methods for simulating a function of a tissue. United States: N. p., 2022.
Web.
Varone, Antonio, Wen, Norman, Levner, Daniel, Novak, Richard, McPartlin, Lori, Ingber, Donald E., Choe, Youngjae, Leng, Lian, & Nguyen, Justin K. Open-top microfluidic devices and methods for simulating a function of a tissue. United States.
Varone, Antonio, Wen, Norman, Levner, Daniel, Novak, Richard, McPartlin, Lori, Ingber, Donald E., Choe, Youngjae, Leng, Lian, and Nguyen, Justin K. Tue .
"Open-top microfluidic devices and methods for simulating a function of a tissue". United States. https://www.osti.gov/servlets/purl/1986841.
@article{osti_1986841,
title = {Open-top microfluidic devices and methods for simulating a function of a tissue},
author = {Varone, Antonio and Wen, Norman and Levner, Daniel and Novak, Richard and McPartlin, Lori and Ingber, Donald E. and Choe, Youngjae and Leng, Lian and Nguyen, Justin K.},
abstractNote = {A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2022},
month = {11}
}
Works referenced in this record:
Microfluidic Chip for Accurately Controllable Cell Culture
patent-application, July 2011
- Huang, Yanyi
- US Patent Application 12/529157; 20110183312
Keratinocyte Growth Regulation in Defined Organotypic Cultures Through IL-1-Induced Keratinocyte Growth Factor Expression in Resting Fibroblasts
journal, June 2000
- Maas-Szabowski, Nicole; Stark, Hans-Jürgen; Fusenig, Norbert E.
- Journal of Investigative Dermatology, Vol. 114, Issue 6
Organ mimic device with microchannels and methods of use and manufacturing thereof
patent, February 2014
- Ingber, Donald E.; Huh, Dongeun
- US Patent Document 8,647,861
Automatable Artificial Immune System (AIS)
patent-application, June 2007
- Warren, William L.; Parkhill, Robert; Nguyen, Michael N.
- US Patent Application 11/594171; 20070141552
Cell Culture System
patent-application, February 2014
- Ingber, Donald E.; Kim, Hyun Jung
- US Patent Application 14/001838; 20140038279
Microreactor
patent, February 2009
- Jury, Andrey Zarur; Angelino, Mark D.
- US Patent Document 7,485,454
Bioengineered Skin: The Self-Assembly Approach
journal, January 2013
- Jean, Jessica
- Journal of Tissue Science & Engineering, Vol. 03, Issue 05
Three‐Dimensional Tissue Models of Normal and Diseased Skin
journal, December 2008
- Carlson, Mark W.; Alt‐Holland, Addy; Egles, Christophe
- Current Protocols in Cell Biology, Vol. 41, Issue 1
Array Apparatus for Dividing Single Cell
patent-application, April 2011
- Park, Jeong Won; Jung, Moon Youn; Park, Seon Hee
- US Patent Application 12/860768; 20110082056
Microfluidic Devices with Removable Cover and Methods of Fabrication and Application
patent-application, August 2012
- Cohen, David; May, Andrew; Pieprzyk, Martin
- US Patent Application 13/499879; 20120195810
Integrated human organ-on-chip microphysiological systems
patent-application, January 2015
- Wikswo, John P.; Samson, Philip C.; Block, III, Frank Emmanuel
- US Patent Application 14/362841; 20150004077
Open Top Microfluidic Device for Multiplexing
patent-application, February 2014
- Corwin, Alex David; Filkins, Robert John; Shaikh, Kashan Ali
- US Patent Application 13/595175; 20140055853
Device for cell culture on deformable surfaces
patent, October 2010
- Quinn, Thomas; Majd, Hicham
- US Patent Document 7,807,453
Device for Studying Individual Cells
patent-application, November 2011
- Deutsch, Mordechai
- US Patent Application 13/184631; 20110275543
Organ Mimic Device with Microchannels and Methods of Use and Manufacturing Thereof
patent-application, April 2014
- Ingber, Donald E.; Huh, Dongeun
- US Patent Application 14/099113; 20140093905
A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture
journal, January 2013
- Wagner, Ilka; Materne, Eva-Maria; Brincker, Sven
- Lab on a Chip, Vol. 13, Issue 18
Compositions and Methods Relating to Clonal Progenitor Cells
patent-application, November 2014
- West, Michael; Murai, James T.; Yang, Jay
- US Patent Application 14/238160; 20140349396
Active Microfluidic Membranes
patent-application, April 2011
- Luo, Xiaolong; Rubloff, Gary W.; Berlin, Dean L.
- US Patent Application 12/890017; 20110081677
A new method for studying gradient-induced neutrophil desensitization based on an open microfluidic chamber
journal, January 2010
- Keenan, Thomas M.; Frevert, Charles W.; Wu, Aileen
- Lab Chip, Vol. 10, Issue 1
On-Chip Open Microfluidic Devices for Chemotaxis Studies
journal, July 2012
- Wright, Gus A.; Costa, Lino; Terekhov, Alexander
- Microscopy and Microanalysis, Vol. 18, Issue 4
Microfluidic organs-on-chips
journal, August 2014
- Bhatia, Sangeeta N.; Ingber, Donald E.
- Nature Biotechnology, Vol. 32, Issue 8
Imunomapeamento nas epidermólises bolhosas hereditárias
journal, December 2010
- Oliveira, Zilda Najjar Prado de; Périgo, Alexandre M.; Fukumori, Lígia M. I.
- Anais Brasileiros de Dermatologia, Vol. 85, Issue 6