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Title: Method for forming polymerized microfluidic devices

Abstract

Methods for making a micofluidic device according to embodiments of the present invention include defining a cavity. Polymer precursor solution is positioned in the cavity, and exposed to light to begin the polymerization process and define a microchannel. In some embodiments, after the polymerization process is partially complete, a solvent rinse is performed, or fresh polymer precursor introduced into the microchannel. This may promote removal of unpolymerized material from the microchannel and enable smaller feature sizes. The polymer precursor solution may contain an iniferter. Polymerized features therefore may be capped with the iniferter, which is photoactive. The iniferter may aid later binding of a polyacrylamide gel to the microchannel surface.

Inventors:
 [1];  [2];  [3];  [4];  [2];  [1]
  1. Livermore, CA
  2. Tracy, CA
  3. Pleasanton, CA
  4. Danville, CA
Issue Date:
Research Org.:
Sandia National Laboratories (SNL-CA)
Sponsoring Org.:
USDOE
OSTI Identifier:
1033939
Patent Number(s):
8047829
Application Number:
12/321,881
Assignee:
Sandia Corporation (Livermore, CA)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B - PERFORMING OPERATIONS B81 - MICROSTRUCTURAL TECHNOLOGY B81B - MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Sommer, Gregory J, Hatch, Anson V, Wang, Ying-Chih, Singh, Anup K, Renzi, Ronald F, and Claudnic, Mark R. Method for forming polymerized microfluidic devices. United States: N. p., 2011. Web.
Sommer, Gregory J, Hatch, Anson V, Wang, Ying-Chih, Singh, Anup K, Renzi, Ronald F, & Claudnic, Mark R. Method for forming polymerized microfluidic devices. United States.
Sommer, Gregory J, Hatch, Anson V, Wang, Ying-Chih, Singh, Anup K, Renzi, Ronald F, and Claudnic, Mark R. Tue . "Method for forming polymerized microfluidic devices". United States. https://www.osti.gov/servlets/purl/1033939.
@article{osti_1033939,
title = {Method for forming polymerized microfluidic devices},
author = {Sommer, Gregory J and Hatch, Anson V and Wang, Ying-Chih and Singh, Anup K and Renzi, Ronald F and Claudnic, Mark R},
abstractNote = {Methods for making a micofluidic device according to embodiments of the present invention include defining a cavity. Polymer precursor solution is positioned in the cavity, and exposed to light to begin the polymerization process and define a microchannel. In some embodiments, after the polymerization process is partially complete, a solvent rinse is performed, or fresh polymer precursor introduced into the microchannel. This may promote removal of unpolymerized material from the microchannel and enable smaller feature sizes. The polymer precursor solution may contain an iniferter. Polymerized features therefore may be capped with the iniferter, which is photoactive. The iniferter may aid later binding of a polyacrylamide gel to the microchannel surface.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 01 00:00:00 EDT 2011},
month = {Tue Nov 01 00:00:00 EDT 2011}
}

Works referenced in this record:

3D polymeric microfluidic device fabrication via contact liquid photolithographic polymerization (CLiPP)
journal, January 2006


Initiation and kinetics of thiol-ene photopolymerizations without photoinitiators
journal, January 2004


Ultra rapid prototyping of microfluidic systems using liquid phase photopolymerization
journal, January 2002


Robust polymer microfluidic device fabrication via contact liquid photolithographic polymerization (CLiPP)
journal, January 2004


Bio-particle separation using microfluidic porous plug for environmental monitoring
journal, January 2007


Microfluidic tectonics: A comprehensive construction platform for microfluidic systems
journal, November 2000