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Title: Microfluidic devices and methods including porous polymer monoliths

Patent ·
OSTI ID:1129389

Microfluidic devices and methods including porous polymer monoliths are described. Polymerization techniques may be used to generate porous polymer monoliths having pores defined by a liquid component of a fluid mixture. The fluid mixture may contain iniferters and the resulting porous polymer monolith may include surfaces terminated with iniferter species. Capture molecules may then be grafted to the monolith pores.

Research Organization:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC04-94AL85000
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Number(s):
8,703,058
Application Number:
12/556,459
OSTI ID:
1129389
Country of Publication:
United States
Language:
English

References (15)

Photopatterning Enzymes on Polymer Monoliths in Microfluidic Devices for Steady-State Kinetic Analysis and Spatially Separated Multi-Enzyme Reactions journal September 2007
Controlled photopolymerization reactions: The reactivity of new photoiniferters journal January 2007
Use of photopatterned porous polymer monoliths as passive micromixers to enhance mixing efficiency for on-chip labeling reactions journal January 2009
Towards stationary phases for chromatography on a microchip: Molded porous polymer monoliths prepared in capillaries by photoinitiated in situ polymerization as separation media for electrochromatography journal January 2000
Iniferter concept and living radical polymerization journal June 2000
Conduct-as-Cast Polymer Monoliths as Separation Media for Capillary Electrochromatography journal March 2001
Monolithic Porous Polymer for On-Chip Solid-Phase Extraction and Preconcentration Prepared by Photoinitiated in Situ Polymerization within a Microfluidic Device journal November 2001
Fabrication of porous polymer monoliths covalently attached to the walls of channels in plastic microdevices journal November 2003
Photografting and the Control of Surface Chemistry in Three-Dimensional Porous Polymer Monoliths journal March 2003
Microchip Dialysis of Proteins Using in Situ Photopatterned Nanoporous Polymer Membranes journal April 2004
Immobilized microfluidic enzymatic reactors journal November 2004
Surface Grafted Antibodies:  Controlled Architecture Permits Enhanced Antigen Detection journal November 2005
Patternable Protein Resistant Surfaces for Multifunctional Microfluidic Devices via Surface Hydrophilization of Porous Polymer Monoliths Using Photografting journal December 2006
Detection of Antigens in Biologically Complex Fluids with Photografted Whole Antibodies journal May 2006
Bio-particle separation using microfluidic porous plug for environmental monitoring journal January 2007