Microfluidic devices and methods including porous polymer monoliths

Hatch, Anson V.; Sommer, Gregory j.; Singh, Anup K.; Wang, Ying-Chih; Abhyankar, Vinay

Microfluidic devices and methods including porous polymer monoliths

Patent · Tue Dec 01 04:00:00 EST 2015

OSTI ID:1227358

Hatch, Anson V.; Sommer, Gregory j.; Singh, Anup K.; Wang, Ying-Chih; Abhyankar, Vinay

Microfluidic devices and methods including porous polymer monoliths are described. Polymerization techniques may be used to generate porous polymer monoliths having pores defined by a liquid component of a fluid mixture. The fluid mixture may contain iniferters and the resulting porous polymer monolith may include surfaces terminated with iniferter species. Capture molecules may then be grafted to the monolith pores.

View Patent

Research Organization:: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC04-94AL85000

Assignee:: Sandia Corporation

Patent Number(s):: 9,201,069

Application Number:: 14/189,949

OSTI ID:: 1227358

Country of Publication:: United States

Language:: English

References (19)

Bio-particle separation using microfluidic porous plug for environmental monitoring Chon, Kyongmi; Moon, Jihee; Kim, Suhan Desalination, Vol. 202, Issue 1-3, p. 215-223 https://doi.org/10.1016/j.desal.2005.12.057	journal	January 2007
Less common applications of monoliths: IV. Recent developments in immobilized enzyme reactors for proteomics and biotechnology Krenkova, Jana; Svec, Frantisek Journal of Separation Science https://doi.org/10.1002/jssc.200800641	journal	February 2009
Use of photopatterned porous polymer monoliths as passive micromixers to enhance mixing efficiency for on-chip labeling reactions Mair, Dieudonne A.; Schwei, Thomas R.; Dinio, Theresa S. Lab on a Chip, Vol. 9, Issue 7 https://doi.org/10.1039/B816521A	journal	January 2009
Detection of Antigens in Biologically Complex Fluids with Photografted Whole Antibodies Sebra, Robert P.; Masters, Kristyn S.; Cheung, Charles Y. Analytical Chemistry, Vol. 78, Issue 9 https://doi.org/10.1021/ac052246y	journal	May 2006
Patternable Protein Resistant Surfaces for Multifunctional Microfluidic Devices via Surface Hydrophilization of Porous Polymer Monoliths Using Photografting Stachowiak, Timothy B.; Svec, Frantisek; Fréchet, Jean M. J. Chemistry of Materials, Vol. 18, Issue 25 https://doi.org/10.1021/cm0617034	journal	December 2006
Immobilized microfluidic enzymatic reactors K?enkov�, Jana; Foret, Franti?ek ELECTROPHORESIS, Vol. 25, Issue 21-22 https://doi.org/10.1002/elps.200406096	journal	November 2004
Fabrication of porous polymer monoliths covalently attached to the walls of channels in plastic microdevices Stachowiak, Timothy B.; Rohr, Thomas; Hilder, Emily F. ELECTROPHORESIS, Vol. 24, Issue 21 https://doi.org/10.1002/elps.200305536	journal	November 2003
Monolithic Porous Polymer for On-Chip Solid-Phase Extraction and Preconcentration Prepared by Photoinitiated in Situ Polymerization within a Microfluidic Device Yu, Cong; Davey, Mark H.; Svec, Frantisek Analytical Chemistry, Vol. 73, Issue 21 https://doi.org/10.1021/ac0106288	journal	November 2001
Preparation of monolithic polymers with controlled porous properties for microfluidic chip applications using photoinitiated free-radical polymerization: Monolithic Polymers Yu, Cong; Xu, Mingcheng; Svec, Frantisek Journal of Polymer Science Part A: Polymer Chemistry, Vol. 40, Issue 6 https://doi.org/10.1002/pola.10155	journal	January 2002
Controlled photopolymerization reactions: The reactivity of new photoiniferters Lalevée, J.; El-Roz, M.; Allonas, X. Journal of Polymer Science Part A: Polymer Chemistry, Vol. 45, Issue 12 https://doi.org/10.1002/pola.22005	journal	January 2007
Photografting and the Control of Surface Chemistry in Three-Dimensional Porous Polymer Monoliths Rohr, Thomas; Hilder, Emily F.; Donovan, John J. Macromolecules, Vol. 36, Issue 5 https://doi.org/10.1021/ma021351w	journal	March 2003
Microchip Dialysis of Proteins Using in Situ Photopatterned Nanoporous Polymer Membranes Song, Simon; Singh, Anup K.; Shepodd, Timothy J. Analytical Chemistry, Vol. 76, Issue 8 https://doi.org/10.1021/ac035290r	journal	April 2004
Iniferter concept and living radical polymerization Otsu, Takayuki Journal of Polymer Science Part A: Polymer Chemistry, Vol. 38, Issue 12, p. 2121-2136 https://doi.org/10.1002/(SICI)1099-0518(20000615)38:12<2121::AID-POLA10>3.0.CO;2-X	journal	June 2000
Optimal Design of Microarray Immunoassays to Compensate for Kinetic Limitations: Theory and Experiment Kusnezow, Wlad; Syagailo, Yana V.; Rüffer, Sven Molecular & Cellular Proteomics, Vol. 5, Issue 9 https://doi.org/10.1074/mcp.T500035-MCP200	journal	May 2006
In situ fabrication of macroporous polymer networks within microfluidic devices by living radical photopolymerization and leaching Simms, Helen M.; Brotherton, Christopher M.; Good, Brian T. Lab on a Chip, Vol. 5, Issue 2 https://doi.org/10.1039/B412589D	journal	January 2005
Surface Grafted Antibodies: Controlled Architecture Permits Enhanced Antigen Detection Sebra, Robert P.; Masters, Kristyn S.; Bowman, Christopher N. Langmuir, Vol. 21, Issue 24 https://doi.org/10.1021/la052101m	journal	November 2005
Conduct-as-Cast Polymer Monoliths as Separation Media for Capillary Electrochromatography Ngola, Sarah M.; Fintschenko, Yolanda; Choi, Wen-Yee Analytical Chemistry, Vol. 73, Issue 5 https://doi.org/10.1021/ac000839x	journal	March 2001
Photopatterning Enzymes on Polymer Monoliths in Microfluidic Devices for Steady-State Kinetic Analysis and Spatially Separated Multi-Enzyme Reactions Logan, Timothy C.; Clark, Douglas S.; Stachowiak, Timothy B. Analytical Chemistry, Vol. 79, Issue 17 https://doi.org/10.1021/ac070705k	journal	September 2007
Towards stationary phases for chromatography on a microchip: Molded porous polymer monoliths prepared in capillaries by photoinitiated in situ polymerization as separation media for electrochromatography Yu, Cong; Svec, Frantisek; Fréchet, Jean M. J. Electrophoresis, Vol. 21, Issue 1, p. 120-127 https://doi.org/10.1002/(SICI)1522-2683(20000101)21:1<120::AID-ELPS120>3.0.CO;2-H	journal	January 2000

Similar Records

Microfluidic devices and methods including porous polymer monoliths

Patent · Tue Apr 22 00:00:00 EDT 2014 · OSTI ID:1129389

Photoinitiated grafting of porous polymer monoliths and thermoplastic polymers for microfluidic devices

Patent · Tue Oct 07 00:00:00 EDT 2008 · OSTI ID:985414

Method for forming polymerized microfluidic devices

Patent · Tue Mar 12 00:00:00 EDT 2013 · OSTI ID:1083062

Related Subjects

36 MATERIALS SCIENCE

Microfluidic devices and methods including porous polymer monoliths

Citation Formats

References (19)

Similar Records

Related Subjects