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Microfluidic devices and methods including porous polymer monoliths

Patent ·
OSTI ID:1129389
Microfluidic devices and methods including porous polymer monoliths are described. Polymerization techniques may be used to generate porous polymer monoliths having pores defined by a liquid component of a fluid mixture. The fluid mixture may contain iniferters and the resulting porous polymer monolith may include surfaces terminated with iniferter species. Capture molecules may then be grafted to the monolith pores.
Research Organization:
SNL (Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States))
Sponsoring Organization:
USDOE
DOE Contract Number:
AC04-94AL85000;
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Number(s):
8,703,058
Application Number:
12/556,459
OSTI ID:
1129389
Country of Publication:
United States
Language:
English

References (16)

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Fabrication of porous polymer monoliths covalently attached to the walls of channels in plastic microdevices journal November 2003
Immobilized microfluidic enzymatic reactors journal November 2004
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Bio-particle separation using microfluidic porous plug for environmental monitoring journal January 2007
Conduct-as-Cast Polymer Monoliths as Separation Media for Capillary Electrochromatography journal March 2001
Monolithic Porous Polymer for On-Chip Solid-Phase Extraction and Preconcentration Prepared by Photoinitiated in Situ Polymerization within a Microfluidic Device journal November 2001
Microchip Dialysis of Proteins Using in Situ Photopatterned Nanoporous Polymer Membranes journal April 2004
Detection of Antigens in Biologically Complex Fluids with Photografted Whole Antibodies journal May 2006
Photopatterning Enzymes on Polymer Monoliths in Microfluidic Devices for Steady-State Kinetic Analysis and Spatially Separated Multi-Enzyme Reactions journal September 2007
Patternable Protein Resistant Surfaces for Multifunctional Microfluidic Devices via Surface Hydrophilization of Porous Polymer Monoliths Using Photografting journal December 2006
Surface Grafted Antibodies:  Controlled Architecture Permits Enhanced Antigen Detection journal November 2005
Photografting and the Control of Surface Chemistry in Three-Dimensional Porous Polymer Monoliths journal March 2003
In situ fabrication of macroporous polymer networks within microfluidic devices by living radical photopolymerization and leaching journal January 2005
Use of photopatterned porous polymer monoliths as passive micromixers to enhance mixing efficiency for on-chip labeling reactions journal January 2009