Methods for integrating a functional component into a microfluidic device

Simmons, Blake; Domeier, Linda; Woo, Noble; Shepodd, Timothy; Renzi, Ronald F.

Title: Methods for integrating a functional component into a microfluidic device

Abstract

Injection molding is used to form microfluidic devices with integrated functional components. One or more functional components are placed in a mold cavity, which is then closed. Molten thermoplastic resin is injected into the mold and then cooled, thereby forming a solid substrate including the functional component(s). The solid substrate including the functional component(s) is then bonded to a second substrate, which may include microchannels or other features.

Inventors:: Simmons, Blake; Domeier, Linda; Woo, Noble; Shepodd, Timothy; Renzi, Ronald F.

Issue Date:: 2014-08-19

Research Org.:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1150712

Patent Number(s):: 8808588

Application Number:: 12/012,653

Assignee:: Sandia Corporation (Albuquerque, NM)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B81 - MICROSTRUCTURAL TECHNOLOGY B81C - PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS

F - MECHANICAL ENGINEERING F15 - FLUID-PRESSURE ACTUATORS F15C - FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES

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B - PERFORMING OPERATIONS B81 - MICROSTRUCTURAL TECHNOLOGY B81C - PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
B81C2201/034 - Moulding
B81C3/002 - {Aligning microparts}

F - MECHANICAL ENGINEERING F15 - FLUID-PRESSURE ACTUATORS F15C - FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
F15C5/00 - Manufacture of fluid circuit elements

F - MECHANICAL ENGINEERING F16 - ENGINEERING ELEMENTS AND UNITS F16K - VALVES
F16K2099/0076 - {using electrical discharge machining [EDM], milling or drilling}
F16K2099/0078 - {using moulding or stamping}
F16K2099/008 - {Multi-layer fabrications}
F16K99/0001 - {Microvalves

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/11 - Automated chemical analysis
Y10T436/2575 - Volumetric liquid transfer

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DOE Contract Number:: AC04-94AL85000

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Simmons, Blake, Domeier, Linda, Woo, Noble, Shepodd, Timothy, and Renzi, Ronald F. Methods for integrating a functional component into a microfluidic device.  United States: N. p., 2014. 
        Web.

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                    Simmons, Blake, Domeier, Linda, Woo, Noble, Shepodd, Timothy, & Renzi, Ronald F. Methods for integrating a functional component into a microfluidic device.  United States.

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                    Simmons, Blake, Domeier, Linda, Woo, Noble, Shepodd, Timothy, and Renzi, Ronald F. Tue .  
        "Methods for integrating a functional component into a microfluidic device".  United States.  https://www.osti.gov/servlets/purl/1150712.

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@article{osti_1150712,

  title        = {Methods for integrating a functional component into a microfluidic device},

  author       = {Simmons, Blake and Domeier, Linda and Woo, Noble and Shepodd, Timothy and Renzi, Ronald F.},

  abstractNote = {Injection molding is used to form microfluidic devices with integrated functional components. One or more functional components are placed in a mold cavity, which is then closed. Molten thermoplastic resin is injected into the mold and then cooled, thereby forming a solid substrate including the functional component(s). The solid substrate including the functional component(s) is then bonded to a second substrate, which may include microchannels or other features.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2014},

  month        = {8}

}

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Title: Methods for integrating a functional component into a microfluidic device

Abstract

Citation Formats

Multi-size injector port system patent, December 1988

Connectorized capillaries for use with separation instrumentation components patent, April 1998

Micromachined fluidic coupler patent, April 1999

Methods of fabricating polymeric structures incorporating microscale fluidic elements patent, September 2000

Microfluidic interconnects patent, April 2001

Microfluidic interconnects patent, August 2001

Method of making a fluid connection patent, September 2001

Microfluidic connector patent, November 2001

Micromachined fluidic coupler and method of making the same patent, August 2002

External material accession systems and methods patent, September 2002

Multilevel flow structures patent, September 2003

Microfluidic devices having embedded metal conductors and methods of fabricating said devices patent, September 2004

Microfluidic fuel cell systems with embedded materials and structures and method thereof patent, July 2005

Microfluidic systems with embedded materials and structures and method thereof patent, March 2007

Microfluidic device for enabling fluidic isolation among interconnected compartments within the apparatus and methods relating to same patent, September 2008

Integrated sample analysis device patent-application, February 2002

Multilevel flow structures patent-application, June 2002

Micromachined rubber O-ring microfluidic couplers patent-application, July 2002

Microfluidic devices for introducing and dispensing fluids from microfluidic systems patent-application, August 2002

Methods and devices for high throughput fluid delivery patent-application, September 2002

Polymer-based platform for microfluidic systems patent-application, September 2002

Microfluidic devices patent-application, February 2003

Sample preparation integrated chip patent-application, July 2003

Microfluidic fuel cell systems with embedded materials and structures and method thereof patent-application, October 2003

Microfluidic devices for high gradient magnetic separation patent-application, January 2004

Microfludic Multi-Compartment Device for Neuroscience Research patent-application, June 2004

Method of manufacturing a microfluidic structure, in particular a biochip, and structure obtained by said method patent-application, December 2004

Microfabricated structures and processes for manufacturing same patent-application, March 2005

Multi-size injector port system
patent, December 1988

Connectorized capillaries for use with separation instrumentation components
patent, April 1998

Micromachined fluidic coupler
patent, April 1999

Methods of fabricating polymeric structures incorporating microscale fluidic elements
patent, September 2000

Microfluidic interconnects
patent, April 2001

Microfluidic interconnects
patent, August 2001

Method of making a fluid connection
patent, September 2001

Microfluidic connector
patent, November 2001

Micromachined fluidic coupler and method of making the same
patent, August 2002

External material accession systems and methods
patent, September 2002

Multilevel flow structures
patent, September 2003

Microfluidic devices having embedded metal conductors and methods of fabricating said devices
patent, September 2004

Microfluidic fuel cell systems with embedded materials and structures and method thereof
patent, July 2005

Microfluidic systems with embedded materials and structures and method thereof
patent, March 2007

Microfluidic device for enabling fluidic isolation among interconnected compartments within the apparatus and methods relating to same
patent, September 2008

Integrated sample analysis device
patent-application, February 2002

Multilevel flow structures
patent-application, June 2002

Micromachined rubber O-ring microfluidic couplers
patent-application, July 2002

Microfluidic devices for introducing and dispensing fluids from microfluidic systems
patent-application, August 2002

Methods and devices for high throughput fluid delivery
patent-application, September 2002

Polymer-based platform for microfluidic systems
patent-application, September 2002

Microfluidic devices
patent-application, February 2003

Sample preparation integrated chip
patent-application, July 2003

Microfluidic fuel cell systems with embedded materials and structures and method thereof
patent-application, October 2003

Microfluidic devices for high gradient magnetic separation
patent-application, January 2004

Microfludic Multi-Compartment Device for Neuroscience Research
patent-application, June 2004

Method of manufacturing a microfluidic structure, in particular a biochip, and structure obtained by said method
patent-application, December 2004

Microfabricated structures and processes for manufacturing same
patent-application, March 2005