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Title: Production of isotopes using high power proton beams

Abstract

The invention provides for a method for producing isotopes using a beam of particles from an accelerator, whereby the beam is maintained at between about 70 to 2000 MeV; and contacting a thorium-containing target with the particles. The medically important isotope .sup.225Ac is produced via the nuclear reaction (p,2p6n), whereby an energetic proton causes the ejection of 2 protons and 6 neutrons from a .sup.232Th target nucleus. Another medically important isotope .sup.213Bi is then available as a decay product. The production of highly purified .sup.211At is also provided.

Inventors:
;
Issue Date:
Research Org.:
Argonne National Laboratory (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1568155
Patent Number(s):
10249399
Application Number:
14/949,665
Assignee:
UChicago Argonne, LLC (Chicago, IL)
Patent Classifications (CPCs):
G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
DOE Contract Number:  
AC02-06CH11357
Resource Type:
Patent
Resource Relation:
Patent File Date: 11/23/2015
Country of Publication:
United States
Language:
English

Citation Formats

Nolen, Jr., Jerry A., and Gomes, Itacil C.. Production of isotopes using high power proton beams. United States: N. p., 2019. Web.
Nolen, Jr., Jerry A., & Gomes, Itacil C.. Production of isotopes using high power proton beams. United States.
Nolen, Jr., Jerry A., and Gomes, Itacil C.. Tue . "Production of isotopes using high power proton beams". United States. https://www.osti.gov/servlets/purl/1568155.
@article{osti_1568155,
title = {Production of isotopes using high power proton beams},
author = {Nolen, Jr., Jerry A. and Gomes, Itacil C.},
abstractNote = {The invention provides for a method for producing isotopes using a beam of particles from an accelerator, whereby the beam is maintained at between about 70 to 2000 MeV; and contacting a thorium-containing target with the particles. The medically important isotope .sup.225Ac is produced via the nuclear reaction (p,2p6n), whereby an energetic proton causes the ejection of 2 protons and 6 neutrons from a .sup.232Th target nucleus. Another medically important isotope .sup.213Bi is then available as a decay product. The production of highly purified .sup.211At is also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {4}
}

Works referenced in this record:

Actinium-225 complexes and conjugates for targeted radiotherapy
patent, December 2003


Method for Production of Radioisotope Preparations and Their Use in Life Science, Research, Medical Application and Industry
patent-application, June 2009


Process for producing astatine-211 for radiopharmaceutical use
patent, July 1987


Transmutable radiotherapy device
patent, September 2001


Actinium radioisotope products of enhanced purity
patent, June 2010


Method for producing Ac-225 by irradiation of Ra-226 with protons
patent, October 2001


Radiotherapy
patent, June 2006


Process and apparatus for the production of BI-213 cations
patent, December 1998


Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine
patent-application, October 2002


Method of producing Actinium-225 and daughters
patent, January 2004


Method for producing actinium-225 and bismuth-213
patent, October 1994