Production of isotopes using high power proton beams

Nolen, Jerry A.; Gomes, Itacil C.

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Title: Production of isotopes using high power proton beams

Abstract

The invention provides for a method for producing isotopes using a beam of particles from an accelerator, whereby the beam is maintained at between about 70 to 2000 MeV; and contacting a thorium-containing target with the particles. The medically important isotope .sup.225Ac is produced via the nuclear reaction (p,2p6n), whereby an energetic proton causes the ejection of 2 protons and 6 neutrons from a .sup.232Th target nucleus. Another medically important isotope .sup.213Bi is then available as a decay product. The production of highly purified .sup.211At is also provided.

Inventors:: Nolen, Jr., Jerry A.; Gomes, Itacil C.

Issue Date:: 2015-12-01

Research Org.:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1345367

Patent Number(s):: 9202602

Application Number:: 13/025,079

Assignee:: UCHICAGO ARGONNE, LLC (Chicago, IL)

Patent Classifications (CPCs):: G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS

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G - PHYSICS G21 - NUCLEAR PHYSICS G21G - CONVERSION OF CHEMICAL ELEMENTS
G21G1/001 - {Recovery of specific isotopes from irradiated targets}
G21G1/10 - by bombardment with electrically charged particles
G21G2001/0084 - {Bismuth}
G21G2001/0089 - {Actinium}
G21G2001/0094 - {Other isotopes not provided for in the groups listed above}

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DOE Contract Number:: AC02-06CH11357

Resource Type:: Patent

Resource Relation:: Patent File Date: 2011 Feb 10

Country of Publication:: United States

Language:: English

Subject:: 43 PARTICLE ACCELERATORS

Citation Formats


                    Nolen, Jr., Jerry A., and Gomes, Itacil C. Production of isotopes using high power proton beams.  United States: N. p., 2015. 
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                    Nolen, Jr., Jerry A., & Gomes, Itacil C. Production of isotopes using high power proton beams.  United States.

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                    Nolen, Jr., Jerry A., and Gomes, Itacil C. Tue .  
        "Production of isotopes using high power proton beams".  United States.  https://www.osti.gov/servlets/purl/1345367.

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@article{osti_1345367,

  title        = {Production of isotopes using high power proton beams},

  author       = {Nolen, Jr., Jerry A. and Gomes, Itacil C.},

  abstractNote = {The invention provides for a method for producing isotopes using a beam of particles from an accelerator, whereby the beam is maintained at between about 70 to 2000 MeV; and contacting a thorium-containing target with the particles. The medically important isotope .sup.225Ac is produced via the nuclear reaction (p,2p6n), whereby an energetic proton causes the ejection of 2 protons and 6 neutrons from a .sup.232Th target nucleus. Another medically important isotope .sup.213Bi is then available as a decay product. The production of highly purified .sup.211At is also provided.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2015},

  month        = {12}

}

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Works referenced in this record:

Separation of Actinium and Thorium from Uranium and Its Daughters
patent, March 1969

Swanson, Donald H.
US Patent Document 3434809
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Target arrangement for spallation-neutron-sources
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Aqueous liquid bleaching detergents which are stable during storage and washing process
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Method for producing actinium-225 and bismuth-213
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Process and apparatus for the production of BI-213 cations
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Transmutable radiotherapy device
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Method for producing Ac-225 by irradiation of Ra-226 with protons
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Actinium-225 complexes and conjugates for targeted radiotherapy
patent, December 2003

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Method of producing Actinium-225 and daughters
patent, January 2004

Satz, Stanley; Schenter, Scott
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Spallation device for producing neutrons
patent, May 2005

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Actinium radioisotope products of enhanced purity
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Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine
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Similar Records

Title: Production of isotopes using high power proton beams

Abstract

Citation Formats

Separation of Actinium and Thorium from Uranium and Its Daughters patent, March 1969

Target arrangement for spallation-neutron-sources patent, April 1986

Method for the simultaneous preparation of Radon-211, Xenon-125, Xenon-123, Astatine-211, Iodine-125 and Iodine-123 patent, May 1987

Process for producing astatine-211 for radiopharmaceutical use patent, July 1987

Aqueous liquid bleaching detergents which are stable during storage and washing process patent, November 1992

Method for producing actinium-225 and bismuth-213 patent, October 1994

Process and apparatus for the production of BI-213 cations patent, December 1998

Transmutable radiotherapy device patent, September 2001

Method for producing Ac-225 by irradiation of Ra-226 with protons patent, October 2001

Actinium-225 complexes and conjugates for targeted radiotherapy patent, December 2003

Method of producing Actinium-225 and daughters patent, January 2004

Spallation device for producing neutrons patent, May 2005

Radiotherapy patent, June 2006

Actinium radioisotope products of enhanced purity patent, June 2010

Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine patent-application, October 2002

Method for Production of Radioisotope Preparations and Their Use in Life Science, Research, Medical Application and Industry patent-application, June 2009

Spallation of Uranium and Thorium Nuclei with Bev-Energy Protons journal, July 1961

Production of 225Ac and 223Ra by irradiation of Th with accelerated protons journal, February 2011

Production of Ac-225 from Th-229 for Targeted α Therapy journal, October 2005

Targeted Killing of Virally Infected Cells by Radiolabeled Antibodies to Viral Proteins journal, November 2006

Targeted α-particle radiotherapy with 211At-labeled monoclonal antibodies journal, October 2007

Cancer Therapy with Alpha-Emitters Labeled Peptides journal, May 2010

Separation of Actinium and Thorium from Uranium and Its Daughters
patent, March 1969

Target arrangement for spallation-neutron-sources
patent, April 1986

Method for the simultaneous preparation of Radon-211, Xenon-125, Xenon-123, Astatine-211, Iodine-125 and Iodine-123
patent, May 1987

Process for producing astatine-211 for radiopharmaceutical use
patent, July 1987

Aqueous liquid bleaching detergents which are stable during storage and washing process
patent, November 1992

Method for producing actinium-225 and bismuth-213
patent, October 1994

Process and apparatus for the production of BI-213 cations
patent, December 1998

Transmutable radiotherapy device
patent, September 2001

Method for producing Ac-225 by irradiation of Ra-226 with protons
patent, October 2001

Actinium-225 complexes and conjugates for targeted radiotherapy
patent, December 2003

Method of producing Actinium-225 and daughters
patent, January 2004

Spallation device for producing neutrons
patent, May 2005

Radiotherapy
patent, June 2006

Actinium radioisotope products of enhanced purity
patent, June 2010

Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine
patent-application, October 2002

Method for Production of Radioisotope Preparations and Their Use in Life Science, Research, Medical Application and Industry
patent-application, June 2009

Spallation of Uranium and Thorium Nuclei with Bev-Energy Protons
journal, July 1961

Production of ²²⁵Ac and ²²³Ra by irradiation of Th with accelerated protons
journal, February 2011

Production of Ac-225 from Th-229 for Targeted α Therapy
journal, October 2005

Targeted Killing of Virally Infected Cells by Radiolabeled Antibodies to Viral Proteins
journal, November 2006

Targeted α-particle radiotherapy with ²¹¹At-labeled monoclonal antibodies
journal, October 2007

Cancer Therapy with Alpha-Emitters Labeled Peptides
journal, May 2010