Production of isotopes using high power proton beams

Title: Production of isotopes using high power proton beams

The invention provides for a method for producing isotopes using a beam of particles from an accelerator, whereby the beam is maintained at between about 70 to 2000 MeV; and contacting a thorium-containing target with the particles. The medically important isotope .sup.225Ac is produced via the nuclear reaction (p,2p6n), whereby an energetic proton causes the ejection of 2 protons and 6 neutrons from a .sup.232Th target nucleus. Another medically important isotope .sup.213Bi is then available as a decay product. The production of highly purified .sup.211At is also provided.

Inventors:: Nolen, Jr., Jerry A.; Gomes, Itacil C.

Issue Date:: 2015-12-01

OSTI Identifier:: 1345367

Assignee:: UCHICAGO ARGONNE, LLC (Chicago, IL) ANL

Patent Number(s):: 9,202,602

Application Number:: 13/025,079

Contract Number:: AC02-06CH11357

Resource Relation:: Patent File Date: 2011 Feb 10

Research Org:: Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 43 PARTICLE ACCELERATORS

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Other works cited in this record:

Production of ²²⁵Ac and ²²³Ra by irradiation of Th with accelerated protons
journal, February 2011

Zhuikov, B. L.; Kalmykov, S. N.; Ermolaev, S. V.
Radiochemistry, Vol. 53, Issue 1, p. 73-80
DOI: 10.1134/S1066362211010103

Targeted α-particle radiotherapy with ²¹¹At-labeled monoclonal antibodies
journal, October 2007

Zalutsky, Michael R.; Reardon, David A.; Pozzi, Oscar R.
Nuclear Medicine and Biology, Vol. 34, Issue 7, p. 779-785
DOI: 10.1016/j.nucmedbio.2007.03.007

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