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Title: Production of isotopes using high power proton beams

Abstract

The invention provides for a method for producing isotopes using a beam of particles from an accelerator, whereby the beam is maintained at between about 70 to 2000 MeV; and contacting a thorium-containing target with the particles. The medically important isotope .sup.225Ac is produced via the nuclear reaction (p,2p6n), whereby an energetic proton causes the ejection of 2 protons and 6 neutrons from a .sup.232Th target nucleus. Another medically important isotope .sup.213Bi is then available as a decay product. The production of highly purified .sup.211At is also provided.

Inventors:
;
Issue Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1345367
Patent Number(s):
9,202,602
Application Number:
13/025,079
Assignee:
UCHICAGO ARGONNE, LLC (Chicago, IL)
DOE Contract Number:  
AC02-06CH11357
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 Feb 10
Country of Publication:
United States
Language:
English
Subject:
43 PARTICLE ACCELERATORS

Citation Formats

Nolen, Jr., Jerry A., and Gomes, Itacil C. Production of isotopes using high power proton beams. United States: N. p., 2015. Web.
Nolen, Jr., Jerry A., & Gomes, Itacil C. Production of isotopes using high power proton beams. United States.
Nolen, Jr., Jerry A., and Gomes, Itacil C. Tue . "Production of isotopes using high power proton beams". United States. https://www.osti.gov/servlets/purl/1345367.
@article{osti_1345367,
title = {Production of isotopes using high power proton beams},
author = {Nolen, Jr., Jerry A. and Gomes, Itacil C.},
abstractNote = {The invention provides for a method for producing isotopes using a beam of particles from an accelerator, whereby the beam is maintained at between about 70 to 2000 MeV; and contacting a thorium-containing target with the particles. The medically important isotope .sup.225Ac is produced via the nuclear reaction (p,2p6n), whereby an energetic proton causes the ejection of 2 protons and 6 neutrons from a .sup.232Th target nucleus. Another medically important isotope .sup.213Bi is then available as a decay product. The production of highly purified .sup.211At is also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {12}
}

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Works referenced in this record:

Spallation of Uranium and Thorium Nuclei with Bev-Energy Protons
journal, July 1961


Production of 225Ac and 223Ra by irradiation of Th with accelerated protons
journal, February 2011


Production of Ac-225 from Th-229 for Targeted α Therapy
journal, October 2005

  • Apostolidis, C.; Molinet, R.; Rasmussen, G.
  • Analytical Chemistry, Vol. 77, Issue 19
  • DOI: 10.1021/ac0580114

Targeted Killing of Virally Infected Cells by Radiolabeled Antibodies to Viral Proteins
journal, November 2006


Targeted α-particle radiotherapy with 211At-labeled monoclonal antibodies
journal, October 2007


Cancer Therapy with Alpha-Emitters Labeled Peptides
journal, May 2010