High temperature and high beam current compatible targets and methods thereof for generating noble gas/radiohalogen generators for medical isotopes

Patent · Tue Oct 03 00:00:00 EDT 2023

OSTI ID:2293674

Sampathkumaran, Uma; Winter, Raymond; Madakashira, Harini

A method of providing alpha particle emitters and materials suitable for use in generating the alpha particles for medical treatment is disclosed. Metal oxide targets, preferentially Bi₂O₃ pellets and Bi₂O₃ coatings on metallic or metal oxide substrates are formed. The targets placed in a heated vacuum chamber subjecting to irradiation using a ⁶Li beam at an elevated temperature below the melting point of the target generate a radioactive gas, such as ²¹¹Rn, the radioactive gas is carried by an inert gas which is delivered a carrier for, such as a carbon column or oil for delivery to a treatment facility. The radioactive gas such as ²¹¹Rn generates ²¹¹At, which has a useable half-life of at least about 14 hours, in turn releases alpha particles which are effective for use in medical procedures.

• Research Organization: Innosense LLC, Torrance, CA (United States)
• Sponsoring Organization: USDOE Office of Science (SC)
• DOE Contract Number: SC0007572; SC0019587
• Assignee: Innosense LLC (Torrance, CA)
• Patent Number(s): 11,776,705
• Application Number: 17/151,147
• OSTI ID: 2293674
• Resource Relation: Patent File Date: 01/16/2021
• Country of Publication: United States
• Language: English