skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Device for detecting molecules, method for detecting molecules

Abstract

A construct is provided that is capable of binding a plurality of molecules, the construct comprising a first moiety with a first molecule binding region and a first molecule non-binding region; and a second moiety with a second molecule-binding region and a second molecule-non-binding region, whereby the first binding region and second binding region are at opposite ends of the construct. Also provided is a method for detecting protein having certain amino acid sequences, the method comprising supplying a collection of proteins each with unknown amino acid sequences, contacting the collection with a moiety having a plurality of binding sites capable of binding with the protein having certain amino acid sequences so as to form a moiety-protein complex, and mixing the complex with a marker specific for the moiety in an amount sufficient to indicate existence of the complex.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1531624
Patent Number(s):
7659083
Application Number:
12/199,683
Assignee:
UChicago Argonne, LLC (Chicago, IL)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
W-31-109-ENG-38
Resource Type:
Patent
Resource Relation:
Patent File Date: 2008-08-27
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Stevens, Fred J., Schiffer, Marianne, Wilkins-Stevens, Priscilla, Hanly, W. Carey, and Tollaksen, Sandra L. Device for detecting molecules, method for detecting molecules. United States: N. p., 2010. Web.
Stevens, Fred J., Schiffer, Marianne, Wilkins-Stevens, Priscilla, Hanly, W. Carey, & Tollaksen, Sandra L. Device for detecting molecules, method for detecting molecules. United States.
Stevens, Fred J., Schiffer, Marianne, Wilkins-Stevens, Priscilla, Hanly, W. Carey, and Tollaksen, Sandra L. Tue . "Device for detecting molecules, method for detecting molecules". United States. https://www.osti.gov/servlets/purl/1531624.
@article{osti_1531624,
title = {Device for detecting molecules, method for detecting molecules},
author = {Stevens, Fred J. and Schiffer, Marianne and Wilkins-Stevens, Priscilla and Hanly, W. Carey and Tollaksen, Sandra L.},
abstractNote = {A construct is provided that is capable of binding a plurality of molecules, the construct comprising a first moiety with a first molecule binding region and a first molecule non-binding region; and a second moiety with a second molecule-binding region and a second molecule-non-binding region, whereby the first binding region and second binding region are at opposite ends of the construct. Also provided is a method for detecting protein having certain amino acid sequences, the method comprising supplying a collection of proteins each with unknown amino acid sequences, contacting the collection with a moiety having a plurality of binding sites capable of binding with the protein having certain amino acid sequences so as to form a moiety-protein complex, and mixing the complex with a marker specific for the moiety in an amount sufficient to indicate existence of the complex.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {2}
}

Patent:

Save / Share:

Works referenced in this record:

Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex.
journal, August 1989


A domain flip as a result of a single amino-acid substitution
journal, August 1998