Device for producing microscopic arrays of molecules, a method for producing microscopic arrays of molecules

Yershov, Gennadiy M.; Belgovskiy, Alexander I.; Mirzabekov, Andrei D.

Title: Device for producing microscopic arrays of molecules, a method for producing microscopic arrays of molecules

Abstract

A device for producing microscopic arrays of molecules is provided, the device comprising a plurality of inverted cavities containing solutions, a substrate adapted to be received by the cavities for extracting the solutions, a substrate for depositing the extracted solutions onto a location on a matrix; and a quality control monitoring system for verifying that the solutions are deposited onto the location on the matrix. A process for producing an array of molecules also is provided, the process comprising providing a plurality of inverted solution cavities, wherein each cavity contains a solution; extracting each solution from its respective inverted cavity; loading each solution at a predetermined position in an array; and verifying that each solution is loaded onto its respective position in the array.

Inventors:: Yershov, Gennadiy M.; Belgovskiy, Alexander I.; Mirzabekov, Andrei D.

Issue Date:: 2004-02-17

Research Org.:: Univ. of Chicago, IL (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1531469

Patent Number(s):: 6692972

Application Number:: 09/645,246

Assignee:: University of Chicago (Chicago, IL)

Patent Classifications (CPCs):: Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

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Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/25625 - Dilution

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J2219/00317 - Microwell devices, i.e. having large numbers of wells
B01J2219/00621 - by physical means, e.g. trenches, raised areas

B - PERFORMING OPERATIONS B81 - MICROSTRUCTURAL TECHNOLOGY B81B - MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
B81B1/00 - Devices without movable or flexible elements, e.g. microcapillary devices

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J2219/00369 - in multiple or parallel arrangements
B01J2219/00693 - Means for quality control
B01J2219/00605 - the compounds being directly bound or immobilised to solid supports

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/25 - including sample preparation

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L3/0244 - {using pins}

C - CHEMISTRY C40 - COMBINATORIAL TECHNOLOGY C40B - COMBINATORIAL CHEMISTRY
C40B60/14 - for creating libraries

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/2575 - Volumetric liquid transfer

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J2219/00659 - Two-dimensional arrays
B01J2219/00644 - the porous medium being present in discrete locations, e.g. gel pads
B01J2219/00585 - Parallel processes
B01J2219/00527 - Sheets

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L3/0262 - {using touch-off at substrate or container}

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
B01J19/0046 - {Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides
B01J2219/00596 - Solid-phase processes

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DOE Contract Number:: W-31-109-ENG-38

Resource Type:: Patent

Resource Relation:: Patent File Date: 2000-08-24

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats


                    Yershov, Gennadiy M., Belgovskiy, Alexander I., and Mirzabekov, Andrei D. Device for producing microscopic arrays of molecules, a method for producing microscopic arrays of molecules.  United States: N. p., 2004. 
        Web.

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                    Yershov, Gennadiy M., Belgovskiy, Alexander I., & Mirzabekov, Andrei D. Device for producing microscopic arrays of molecules, a method for producing microscopic arrays of molecules.  United States.

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                    Yershov, Gennadiy M., Belgovskiy, Alexander I., and Mirzabekov, Andrei D. Tue .  
        "Device for producing microscopic arrays of molecules, a method for producing microscopic arrays of molecules".  United States.  https://www.osti.gov/servlets/purl/1531469.

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@article{osti_1531469,

  title        = {Device for producing microscopic arrays of molecules, a method for producing microscopic arrays of molecules},

  author       = {Yershov, Gennadiy M. and Belgovskiy, Alexander I. and Mirzabekov, Andrei D.},

  abstractNote = {A device for producing microscopic arrays of molecules is provided, the device comprising a plurality of inverted cavities containing solutions, a substrate adapted to be received by the cavities for extracting the solutions, a substrate for depositing the extracted solutions onto a location on a matrix; and a quality control monitoring system for verifying that the solutions are deposited onto the location on the matrix. A process for producing an array of molecules also is provided, the process comprising providing a plurality of inverted solution cavities, wherein each cavity contains a solution; extracting each solution from its respective inverted cavity; loading each solution at a predetermined position in an array; and verifying that each solution is loaded onto its respective position in the array.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2004},

  month        = {2}

}

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Works referenced in this record:

Systems and methods for performing reactions in an unsealed environment
patent, May 2001

Becker, Thomas C.; Koster, Hubert; Cantor, Charles R.
US Patent Document 6,225,061
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6225061

Method and apparatus for aspirating and dispensing sample fluids
patent, May 1998

Dorenkott, Jeffrey S.; Wilder, Steven E.; Nyugen, Dinh
US Patent Document 5,750,881
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5750881

Mass spectrometer system and method for matrix-assisted laser desorption measurements
patent, March 1996

Vestal, Marvin L.
US Patent Document 5,498,545
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5498545

Method and apparatus for automated dispensing
patent, April 2000

Ally, Abdul H.; Schuette, Michael W.
US Patent Document 6,044,876
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6044876

Method and device for liquid transfer with an analysis apparatus
patent, November 2000

Roesicke, Bernd
US Patent Document 6,148,666
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6148666

Systems and methods for rapidly identifying useful chemicals in liquid samples
patent, November 1999

Stylli, Chari; Beckey, Samuel S.; Shumate, Christopher Bentley
US Patent Document 5,985,214
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5985214

Method and apparatus for transferring and dispensing small volumes of liquid and method for making the apparatus
patent, April 2000

Birch, William R.; Carre, Alain; Francois, Eric P.
US Patent Document 6,051,190
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6051190

Laboratory vessel having hydrophobic coating and process for manufacturing same
patent, December 1998

Brown, James F.
US Patent Document 5,853,894
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5853894

Microfabricated structures for facilitating fluid introduction into microfluidic devices
patent, July 2000

Sundberg, Steven A.; Parce, J. Wallace; Chow, Calvin
US Patent Document 6,090,251
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6090251

Systems and methods for preparing low volume analyte array elements
patent, February 2000

Little, Daniel P.; Koster, Hubert
US Patent Document 6,024,925
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6024925

Fluid testing and analysing device and method
patent, April 2000

Dubus, Yves P.
US Patent Document 6,054,326
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6054326

Method and apparatus for high-speed dot array dispensing
patent, May 2000

Tisone, Thomas C.; Tisone, Christopher V.
US Patent Document 6,063,339
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6063339

Automated determining and measuring device and method
patent, November 2000

Schubert, Walter
US Patent Document 6,150,173
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6150173

Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture
patent, August 2000

Martinsky, Richard S.
US Patent Document 6,101,946
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6101946

Works referencing / citing this record:

Modular, micro-scale, optical array and biodetection system
patent, December 2008

Yershov, Gennadiy M.
US Patent Document 7,463,353
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=7463353

Systems and methods for ordering oligonucleotides
patent, December 2011

Fowler, Craig A.; Mehta, Vinod C.; Rosso, Thomas L.
US Patent Document 8,073,666
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=8073666

Temperature controlled microfabricated two-pin liquid sample dispensing system
patent, August 2007

Gilbert, John R.; Bhm, Sebastian
US Patent Document 7,258,839
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=7258839

Fluid dispensing system
patent, November 2009

Gleason, K. Reed; Navratil, Peter; Martin, John
US Patent Document 7,618,590
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=7618590

Gel-forming reagents and uses thereof for preparing microarrays
patent, November 2010

Golova, Julia B.; Chernov, Boris K.; Perov, Alexander N.
US Patent Document 7,829,644
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=7829644

Microfabricated two-pin system for biomolecule crystallization
patent, December 2006

Gilbert, John R.; Trikha, Jaishree
US Patent Document 7,153,699
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=7153699

Oligonucleotide ordering system
patent, January 2010

Fowler, Craig A.; Mehta, Vinod C.; Rosso, Thomas L.
US Patent Document 7,647,186
URL: http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=7647186

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Title: Device for producing microscopic arrays of molecules, a method for producing microscopic arrays of molecules

Abstract

Citation Formats

Systems and methods for performing reactions in an unsealed environment patent, May 2001

Method and apparatus for aspirating and dispensing sample fluids patent, May 1998

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Microfabricated structures for facilitating fluid introduction into microfluidic devices patent, July 2000

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Method and apparatus for high-speed dot array dispensing patent, May 2000

Automated determining and measuring device and method patent, November 2000

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Method and device for liquid transfer with an analysis apparatus
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Systems and methods for rapidly identifying useful chemicals in liquid samples
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Method and apparatus for transferring and dispensing small volumes of liquid and method for making the apparatus
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