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Title: Methods for the selective detection of alkyne-presenting molecules and related compositions and systems

Abstract

Provided herein are methods for selectively detecting an alkyne-presenting molecule in a sample and related detection reagents, compositions, methods and systems. The methods include contacting a detection reagent with the sample for a time and under a condition to allow binding of the detection reagent to the one or more alkyne-presenting molecules possibly present in the matrix to the detection reagent. The detection reagent includes an organic label moiety presenting an azide group. The binding of the azide group to the alkyne-presenting molecules results in emission of a signal from the organic label moiety.

Inventors:
;
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1400219
Patent Number(s):
9791463
Application Number:
14/201,530
Assignee:
Lawrence Livermore National Security, LLC
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08F - MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
DOE Contract Number:  
AC52-07NA27344
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Mar 07
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Valdez, Carlos A., and Vu, Alexander K. Methods for the selective detection of alkyne-presenting molecules and related compositions and systems. United States: N. p., 2017. Web.
Valdez, Carlos A., & Vu, Alexander K. Methods for the selective detection of alkyne-presenting molecules and related compositions and systems. United States.
Valdez, Carlos A., and Vu, Alexander K. Tue . "Methods for the selective detection of alkyne-presenting molecules and related compositions and systems". United States. https://www.osti.gov/servlets/purl/1400219.
@article{osti_1400219,
title = {Methods for the selective detection of alkyne-presenting molecules and related compositions and systems},
author = {Valdez, Carlos A. and Vu, Alexander K.},
abstractNote = {Provided herein are methods for selectively detecting an alkyne-presenting molecule in a sample and related detection reagents, compositions, methods and systems. The methods include contacting a detection reagent with the sample for a time and under a condition to allow binding of the detection reagent to the one or more alkyne-presenting molecules possibly present in the matrix to the detection reagent. The detection reagent includes an organic label moiety presenting an azide group. The binding of the azide group to the alkyne-presenting molecules results in emission of a signal from the organic label moiety.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {10}
}

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