De novo design of allosteric proteins

Title: De novo design of allosteric proteins

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Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change in the proteins are provided.

Inventors:: Raman, Srivatsan; Taylor, Noah D.; Church, George M.

Issue Date:: 2018-08-07

OSTI Identifier:: 1469336

Assignee:: President and Fellows of Harvard College (Cambridge, MA) CHO

Patent Number(s):: 10,041,065

Application Number:: 15/628,690

Contract Number:: FG02-02ER63445

Resource Relation:: Patent File Date: 2017 Jun 21

Research Org:: President and Fellows of Harvard College, Cambridge, MA (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

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De novo design of allosteric proteins

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Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change in the proteins are provided.
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