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Title: De novo design of allosteric proteins

Abstract

Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change in the proteins are provided.

Inventors:
; ;
Issue Date:
Research Org.:
Harvard Univ., Cambridge, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1373718
Patent Number(s):
9721061
Application Number:
15/120,228
Assignee:
President and Fellows of Harvard College (Cambridge, MA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
FG02-02ER63445
Resource Type:
Patent
Resource Relation:
Patent File Date: 2015 Feb 20
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Raman, Srivatsan, Taylor, Noah D., and Church, George M.. De novo design of allosteric proteins. United States: N. p., 2017. Web.
Raman, Srivatsan, Taylor, Noah D., & Church, George M.. De novo design of allosteric proteins. United States.
Raman, Srivatsan, Taylor, Noah D., and Church, George M.. Tue . "De novo design of allosteric proteins". United States. https://www.osti.gov/servlets/purl/1373718.
@article{osti_1373718,
title = {De novo design of allosteric proteins},
author = {Raman, Srivatsan and Taylor, Noah D. and Church, George M.},
abstractNote = {Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change in the proteins are provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2017},
month = {8}
}

Works referenced in this record:

In Vivo Selection System for Enzyme Activity
patent-application, October 2009


In vivo selection system for enzyme activity
patent, January 2009


Methods of Generating Libraries and Uses Thereof
patent-application, November 2011


The structural basis of allosteric regulation in proteins
journal, March 2009


Light-activated DNA binding in a designed allosteric protein
journal, July 2008