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Title: De novo design of allosteric proteins

Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change in the proteins are provided.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1373718
Assignee:
President and Fellows of Harvard College CHO
Patent Number(s):
9,721,061
Application Number:
15/120,228
Contract Number:
FG02-02ER63445
Resource Relation:
Patent File Date: 2015 Feb 20
Research Org:
President and Fellows of Harvard College, Cambridge, MA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Other works cited in this record:

In vivo selection system for enzyme activity
patent, January 2009

In Vivo Selection System for Enzyme Activity
patent-application, October 2009

Methods of Generating Libraries and Uses Thereof
patent-application, November 2011

The structural basis of allosteric regulation in proteins
journal, March 2009

Light-activated DNA binding in a designed allosteric protein
journal, July 2008
  • Strickland, D.; Moffat, K.; Sosnick, T. R.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 31, p. 10709-10714
  • DOI: 10.1073/pnas.0709610105

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