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Title: De novo design of allosteric proteins

Patent ·
OSTI ID:1568741

Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change in the proteins are provided.

Research Organization:
Harvard Univ., Cambridge, MA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-02ER63445
Assignee:
President and Fellows of Harvard College (Cambridge, MA)
Patent Number(s):
10,385,333
Application Number:
16/039,917
OSTI ID:
1568741
Resource Relation:
Patent File Date: 07/19/2018
Country of Publication:
United States
Language:
English

References (5)

In Vivo Selection System for Enzyme Activity patent-application October 2009
Methods of Generating Libraries and Uses Thereof patent-application November 2011
In vivo selection system for enzyme activity patent January 2009
Engineered stimulus-responsive switches patent-application August 2007
De novo design of allosteric proteins patent August 2017

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