De novo design of allosteric proteins
Abstract
Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change in the proteins are provided.
- Inventors:
- Issue Date:
- Research Org.:
- Harvard Univ., Cambridge, MA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1568741
- Patent Number(s):
- 10385333
- Application Number:
- 16/039,917
- Assignee:
- President and Fellows of Harvard College (Cambridge, MA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- FG02-02ER63445
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 07/19/2018
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Raman, Srivatsan, Taylor, Noah D., and Church, George M. De novo design of allosteric proteins. United States: N. p., 2019.
Web.
Raman, Srivatsan, Taylor, Noah D., & Church, George M. De novo design of allosteric proteins. United States.
Raman, Srivatsan, Taylor, Noah D., and Church, George M. Tue .
"De novo design of allosteric proteins". United States. https://www.osti.gov/servlets/purl/1568741.
@article{osti_1568741,
title = {De novo design of allosteric proteins},
author = {Raman, Srivatsan and Taylor, Noah D. and Church, George M.},
abstractNote = {Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change in the proteins are provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 20 00:00:00 EDT 2019},
month = {Tue Aug 20 00:00:00 EDT 2019}
}
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Works referenced in this record:
In Vivo Selection System for Enzyme Activity
patent-application, October 2009
- Liu, David R.; Gartner, Zev; Rosenbaum, Daniel M.
- US Patent Document Appl. No. 20090263851
Methods of Generating Libraries and Uses Thereof
patent-application, November 2011
- Bowers, Peter M.; Cubitt, Andrew B.; Horlick, Robert A.
- US Patent Document Appl No. 20110287485
In vivo selection system for enzyme activity
patent, January 2009
- Liu, David R.; Gartner, Zev J.; Rosenbaum, Daniel
- US Patent Document 7,476,500
Engineered stimulus-responsive switches
patent-application, August 2007
- Schwartz, John Jacob; Jacobson, Joseph; Das Gupta, Ruchira
- US Patent Application 11/705565; 20070196816
De novo design of allosteric proteins
patent, August 2017
- Raman, Srivatsan; Taylor, Noah D.; Church, George M.
- US Patent Document 9,721,061