System and method for laser assisted sample transfer to solution for chemical analysis

Van Berkel, Gary J; Kertesz, Vilmos

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Title: System and method for laser assisted sample transfer to solution for chemical analysis

Abstract

A system and method for laser desorption of an analyte from a specimen and capturing of the analyte in a suspended solvent to form a testing solution are described. The method can include providing a specimen supported by a desorption region of a specimen stage and desorbing an analyte from a target site of the specimen with a laser beam centered at a radiation wavelength (.lamda.). The desorption region is transparent to the radiation wavelength (.lamda.) and the sampling probe and a laser source emitting the laser beam are on opposite sides of a primary surface of the specimen stage. The system can also be arranged where the laser source and the sampling probe are on the same side of a primary surface of the specimen stage. The testing solution can then be analyzed using an analytical instrument or undergo further processing.

Inventors:: Van Berkel, Gary J; Kertesz, Vilmos

Issue Date:: Tue Jan 28 00:00:00 EST 2014

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1117871

Patent Number(s):: 8637813

Application Number:: 12/896,018

Assignee:: UT-Battelle, LLC (Oak Ridge, TN)

Patent Classifications (CPCs):: H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS

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H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
H01J49/0463 - {Desorption by laser or particle beam, followed by ionisation as a separate step

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DOE Contract Number:: AC05-00OR22725

Resource Type:: Patent

Resource Relation:: Patent File Date: 2010 Oct 01

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

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                    Van Berkel, Gary J, and Kertesz, Vilmos. System and method for laser assisted sample transfer to solution for chemical analysis.  United States: N. p., 2014. 
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                    Van Berkel, Gary J, & Kertesz, Vilmos. System and method for laser assisted sample transfer to solution for chemical analysis.  United States.

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                    Van Berkel, Gary J, and Kertesz, Vilmos. Tue .  
        "System and method for laser assisted sample transfer to solution for chemical analysis".  United States.  https://www.osti.gov/servlets/purl/1117871.

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@article{osti_1117871,

  title        = {System and method for laser assisted sample transfer to solution for chemical analysis},

  author       = {Van Berkel, Gary J and Kertesz, Vilmos},

  abstractNote = {A system and method for laser desorption of an analyte from a specimen and capturing of the analyte in a suspended solvent to form a testing solution are described. The method can include providing a specimen supported by a desorption region of a specimen stage and desorbing an analyte from a target site of the specimen with a laser beam centered at a radiation wavelength (.lamda.). The desorption region is transparent to the radiation wavelength (.lamda.) and the sampling probe and a laser source emitting the laser beam are on opposite sides of a primary surface of the specimen stage. The system can also be arranged where the laser source and the sampling probe are on the same side of a primary surface of the specimen stage. The testing solution can then be analyzed using an analytical instrument or undergo further processing.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jan 28 00:00:00 EST 2014},

  month        = {Tue Jan 28 00:00:00 EST 2014}

}

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Works referencing / citing this record:

System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis
patent, July 2016

Kertesz, Vilmos; Van Berkel, Gary J.
US Patent Document 9,390,901
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9390901

Ionization device, mass spectrometer including the ionization device, and image generation system including the ionization device
patent, February 2016

Otsuka, Yoichi
US Patent Document 9,269,557
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Systems and methods for laser assisted sample transfer to solution for chemical analysis
patent, September 2015

Van Berkel, Gary J.; Kertesz, Vilmos; Ovchinnikova, Olga S.
US Patent Document 9,146,180
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9146180

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Patent Kertesz, Vilmos; Van Berkel, Gary J.

A system for sampling a surface includes a surface sampling probe comprising a solvent liquid supply conduit and a distal end, and a sample collector for suspending a sample collection liquid adjacent to the distal end of the probe. A first electrode provides a first voltage to solvent liquid at the distal end of the probe. The first voltage produces a field sufficient to generate electrospray plume at the distal end of the probe. A second electrode provides a second voltage and is positioned to produce a plume-directing field sufficient to direct the electrospray droplets and ions to the suspendedmore » « less
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Laser-assisted metal-organic chemical vapor deposition devices and methods of use thereof for suppressing background carbon incorporation

Patent Zhao, Hongping; Chen, Zhaoying; Zhang, Yuxuan

Disclosed herein are laser-assisted metal-organic chemical vapor deposition devices and methods of use thereof for suppressing background carbon incorporation.
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Title: System and method for laser assisted sample transfer to solution for chemical analysis

Abstract

Citation Formats

Disposable beverage container patent, February 1988

Disposable combination cup and base patent, September 1989

Recyclable corrugated beverage container and holder patent, April 1993

Method and apparatus for maldi analysis patent, July 1998

System and method for on-line coupling of liquid capillary separations with matrix-assisted laser desorption/ionization mass spectrometry patent, October 2000

Ultra high throughput sampling and analysis systems and methods patent, September 2003

Sampling probe for microarray read out using electrospray mass spectrometry patent, October 2004

Interface members and holders for microfluidic array devices patent, March 2005

Laser desorption—electrospray ion (ESI) source for mass spectrometers patent, April 2009

Acoustic desorption mass spectrometry patent, January 2010

Mass spectroscopic reaction-monitoring method patent, May 2010

Mass spectrometry with laser ablation patent, March 2011

Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry patent, November 2011

Method and apparatus for maldi analysis patent-application, August 2002

Direct flow injection analysis nebulization electrospray and APCI mass spectrometry patent-application, November 2002

Method and apparatus for continuous sample deposition on sample support plates for liquid chromatography-matrix-assisted laser desorption/ionization mass spectrometry patent-application, February 2004

Methods and devices for concentration and purification of analytes for chemical analysis including matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) patent-application, June 2005

Methods and compositions for assessing a sample by maldi mass spectrometry patent-application, August 2005

Container and method of making a container patent-application, December 2005

Multi-function laser induced breakdown spectroscopy and laser ablation material analysis system and method patent-application, March 2007

Automated Analysis Of Complex Matrices Using Mass Spectrometer patent-application, June 2007

Means and method for analyzing samples by mass spectrometry patent-application, September 2007

High power laser induced acoustic desorption probe patent-application, December 2007

Mass Spectrometry With Laser Ablation patent-application, June 2008

Apparatus and method for isolating a nucleic acid from a sample patent-application, June 2008

Laser desorption - electrospray ion (ESI) source for mass spectrometers patent-application, November 2008

Electrospray-Assisted Laser-Induced Acoustic Desorption Ionization Mass Spectrometer and a Method for Mass Spectrometry patent-application, December 2008

Increasing Ionization Efficiency in Mass Spectroscopy patent-application, May 2009

Differential Hemolysis of a Whole Blood Sample patent-application, October 2009

Disposable Containers and Utensils for Sanitizing patent-application, October 2009

Laser Ablation Electrospray Ionization (LAESI) for Atmospheric Pressure, In Vivo, and Imaging Mass Spectrometry patent-application, November 2009

Method of Preparing Sample for Matrix-Assisted Laser Desorption Ionization Mass Spectrometry and Matrix-Assisted Laser Desorption Ionization Mass Spectrometry patent-application, February 2010

Method and system for formation and withdrawal of a sample from a surface to be analyzed patent-application, September 2010

Solid-Phase Extraction (SPE) Tips and Methods of Use patent-application, June 2011

Cycling Electrospray Ionization Device patent-application, September 2011

Beverage Pod patent-application, October 2011

Laser-Induced Acoustic Desorption/ Atmospheric Pressure Chemical Ionization of Compounds patent-application, November 2011

Ion Generation Using Wetted Porous Material patent-application, May 2012

Evidence of near-field laser ablation inductively coupled plasma mass spectrometry (NF-LA-ICP-MS) at nanometre scale for elemental and isotopic analysis on gels and biological samples journal, January 2006

Field enhancement in apertureless near-field scanning optical microscopy journal, January 2001

The irradiation effect of a Nd–YAG pulsed laser on the CeO2 target in the liquid journal, January 2004

Looking at the nanoscale: scanning near-field optical microscopy journal, February 2003

Laser Ablation of a Sample In Liquid—LASIL journal, January 2011

Near-Field Scanning Optical Microscopy journal, October 1999

Transmission studies of explosive vaporization of a transparent liquid film on an opaque solid surface induced by excimer‐laser‐pulsed irradiation journal, September 1992

Laser ablation in liquids as a new technique of sampling in elemental analysis of solid materials journal, February 2009

Near-Field Optical Microscopy and Spectroscopy with Pointed Probes journal, May 2006

Methods for Molecular Nanoanalysis journal, November 2006

Towards Nanoscale Molecular Analysis at Atmospheric Pressure by a Near-Field Laser Ablation Ion Trap/Time-of-Flight Mass Spectrometer journal, September 2008

Nanoscale Atmospheric Pressure Laser Ablation-Mass Spectrometry journal, April 2001

Microsecond-resolved imaging of laser ablation at solid–liquid interface: investigation of formation process of nano-size metal colloids journal, May 2004

Laser ablation in liquids: Applications in the synthesis of nanocrystals journal, May 2007

Laser ablation in a liquid medium as a technique for solid sampling journal, January 1991

Apertureless Metallic Probes for Near-Field Microscopy book, January 2001

Optical reflectance and scattering studies of nucleation and growth of bubbles at a liquid-solid interface induced by pulsed laser heating journal, March 1993

Bubble nucleation and pressure generation during laser cleaning of surfaces journal, April 1997

Pulsed laser‐induced desorption and optical imaging on a nanometer scale with scanning near‐field microscopy using chemically etched fiber tips journal, April 1996

Hollow nanoparticle generation on laser-induced cavitation bubbles via bubble interface pinning journal, September 2010

Possibility of nano-local element analysis by near-field laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS): New experimental arrangement and first application journal, June 2008

System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis patent, July 2016

Ionization device, mass spectrometer including the ionization device, and image generation system including the ionization device patent, February 2016

Systems and methods for laser assisted sample transfer to solution for chemical analysis patent, September 2015

Disposable beverage container
patent, February 1988

Disposable combination cup and base
patent, September 1989

Recyclable corrugated beverage container and holder
patent, April 1993

Method and apparatus for maldi analysis
patent, July 1998

System and method for on-line coupling of liquid capillary separations with matrix-assisted laser desorption/ionization mass spectrometry
patent, October 2000

Ultra high throughput sampling and analysis systems and methods
patent, September 2003

Sampling probe for microarray read out using electrospray mass spectrometry
patent, October 2004

Interface members and holders for microfluidic array devices
patent, March 2005

Laser desorption—electrospray ion (ESI) source for mass spectrometers
patent, April 2009

Acoustic desorption mass spectrometry
patent, January 2010

Mass spectroscopic reaction-monitoring method
patent, May 2010

Mass spectrometry with laser ablation
patent, March 2011

Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry
patent, November 2011

Method and apparatus for maldi analysis
patent-application, August 2002

Direct flow injection analysis nebulization electrospray and APCI mass spectrometry
patent-application, November 2002

Method and apparatus for continuous sample deposition on sample support plates for liquid chromatography-matrix-assisted laser desorption/ionization mass spectrometry
patent-application, February 2004

Methods and devices for concentration and purification of analytes for chemical analysis including matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS)
patent-application, June 2005

Methods and compositions for assessing a sample by maldi mass spectrometry
patent-application, August 2005

Container and method of making a container
patent-application, December 2005

Multi-function laser induced breakdown spectroscopy and laser ablation material analysis system and method
patent-application, March 2007

Automated Analysis Of Complex Matrices Using Mass Spectrometer
patent-application, June 2007

Means and method for analyzing samples by mass spectrometry
patent-application, September 2007

High power laser induced acoustic desorption probe
patent-application, December 2007

Mass Spectrometry With Laser Ablation
patent-application, June 2008

Apparatus and method for isolating a nucleic acid from a sample
patent-application, June 2008

Laser desorption - electrospray ion (ESI) source for mass spectrometers
patent-application, November 2008

Electrospray-Assisted Laser-Induced Acoustic Desorption Ionization Mass Spectrometer and a Method for Mass Spectrometry
patent-application, December 2008

Increasing Ionization Efficiency in Mass Spectroscopy
patent-application, May 2009

Differential Hemolysis of a Whole Blood Sample
patent-application, October 2009

Disposable Containers and Utensils for Sanitizing
patent-application, October 2009

Laser Ablation Electrospray Ionization (LAESI) for Atmospheric Pressure, In Vivo, and Imaging Mass Spectrometry
patent-application, November 2009

Method of Preparing Sample for Matrix-Assisted Laser Desorption Ionization Mass Spectrometry and Matrix-Assisted Laser Desorption Ionization Mass Spectrometry
patent-application, February 2010

Method and system for formation and withdrawal of a sample from a surface to be analyzed
patent-application, September 2010

Solid-Phase Extraction (SPE) Tips and Methods of Use
patent-application, June 2011

Cycling Electrospray Ionization Device
patent-application, September 2011

Beverage Pod
patent-application, October 2011

Laser-Induced Acoustic Desorption/ Atmospheric Pressure Chemical Ionization of Compounds
patent-application, November 2011

Ion Generation Using Wetted Porous Material
patent-application, May 2012

Evidence of near-field laser ablation inductively coupled plasma mass spectrometry (NF-LA-ICP-MS) at nanometre scale for elemental and isotopic analysis on gels and biological samples
journal, January 2006

Field enhancement in apertureless near-field scanning optical microscopy
journal, January 2001

The irradiation effect of a Nd–YAG pulsed laser on the CeO₂ target in the liquid
journal, January 2004

Looking at the nanoscale: scanning near-field optical microscopy
journal, February 2003

Laser Ablation of a Sample In Liquid—LASIL
journal, January 2011

Near-Field Scanning Optical Microscopy
journal, October 1999

Transmission studies of explosive vaporization of a transparent liquid film on an opaque solid surface induced by excimer‐laser‐pulsed irradiation
journal, September 1992

Laser ablation in liquids as a new technique of sampling in elemental analysis of solid materials
journal, February 2009

Near-Field Optical Microscopy and Spectroscopy with Pointed Probes
journal, May 2006

Methods for Molecular Nanoanalysis
journal, November 2006

Towards Nanoscale Molecular Analysis at Atmospheric Pressure by a Near-Field Laser Ablation Ion Trap/Time-of-Flight Mass Spectrometer
journal, September 2008

Nanoscale Atmospheric Pressure Laser Ablation-Mass Spectrometry
journal, April 2001

Microsecond-resolved imaging of laser ablation at solid–liquid interface: investigation of formation process of nano-size metal colloids
journal, May 2004

Laser ablation in liquids: Applications in the synthesis of nanocrystals
journal, May 2007

Laser ablation in a liquid medium as a technique for solid sampling
journal, January 1991

Apertureless Metallic Probes for Near-Field Microscopy
book, January 2001

Optical reflectance and scattering studies of nucleation and growth of bubbles at a liquid-solid interface induced by pulsed laser heating
journal, March 1993

Bubble nucleation and pressure generation during laser cleaning of surfaces
journal, April 1997

Pulsed laser‐induced desorption and optical imaging on a nanometer scale with scanning near‐field microscopy using chemically etched fiber tips
journal, April 1996

Hollow nanoparticle generation on laser-induced cavitation bubbles via bubble interface pinning
journal, September 2010

Possibility of nano-local element analysis by near-field laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS): New experimental arrangement and first application
journal, June 2008

System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis
patent, July 2016

Ionization device, mass spectrometer including the ionization device, and image generation system including the ionization device
patent, February 2016

Systems and methods for laser assisted sample transfer to solution for chemical analysis
patent, September 2015