System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis

Kertesz, Vilmos; Van Berkel, Gary J.

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Title: System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis

Abstract

A system for sampling a surface includes a surface sampling probe comprising a solvent liquid supply conduit and a distal end, and a sample collector for suspending a sample collection liquid adjacent to the distal end of the probe. A first electrode provides a first voltage to solvent liquid at the distal end of the probe. The first voltage produces a field sufficient to generate electrospray plume at the distal end of the probe. A second electrode provides a second voltage and is positioned to produce a plume-directing field sufficient to direct the electrospray droplets and ions to the suspended sample collection liquid. The second voltage is less than the first voltage in absolute value. A voltage supply system supplies the voltages to the first electrode and the second electrode. The first electrode can apply the first voltage directly to the solvent liquid. A method for sampling for a surface is also disclosed.

Inventors:: Kertesz, Vilmos; Van Berkel, Gary J.

Issue Date:: Tue Jul 12 00:00:00 EDT 2016

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1261602

Patent Number(s):: 9390901

Application Number:: 14/529,307

Assignee:: UT-BATTELLE, LLC (Oak Ridge, TN)

Patent Classifications (CPCs):: H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS

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H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
H01J49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks
H01J49/0431 - {for liquid samples
H01J49/142 - {using a solid target which is not previously vapourised}
H01J49/167 - {Capillaries and nozzles specially adapted therefor
H01J49/26 - Mass spectrometers or separator tubes

Show less

DOE Contract Number:: AC05-00OR22725

Resource Type:: Patent

Resource Relation:: Patent File Date: 2014 Oct 31

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 47 OTHER INSTRUMENTATION

Citation Formats


                    Kertesz, Vilmos, and Van Berkel, Gary J. System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis.  United States: N. p., 2016. 
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                    Kertesz, Vilmos, & Van Berkel, Gary J. System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis.  United States.

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                    Kertesz, Vilmos, and Van Berkel, Gary J. Tue .  
        "System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis".  United States.  https://www.osti.gov/servlets/purl/1261602.

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@article{osti_1261602,

  title        = {System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis},

  author       = {Kertesz, Vilmos and Van Berkel, Gary J.},

  abstractNote = {A system for sampling a surface includes a surface sampling probe comprising a solvent liquid supply conduit and a distal end, and a sample collector for suspending a sample collection liquid adjacent to the distal end of the probe. A first electrode provides a first voltage to solvent liquid at the distal end of the probe. The first voltage produces a field sufficient to generate electrospray plume at the distal end of the probe. A second electrode provides a second voltage and is positioned to produce a plume-directing field sufficient to direct the electrospray droplets and ions to the suspended sample collection liquid. The second voltage is less than the first voltage in absolute value. A voltage supply system supplies the voltages to the first electrode and the second electrode. The first electrode can apply the first voltage directly to the solvent liquid. A method for sampling for a surface is also disclosed.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jul 12 00:00:00 EDT 2016},

  month        = {Tue Jul 12 00:00:00 EDT 2016}

}

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Title: System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis

Abstract

Citation Formats

Automated liquid microjunction surface sampling-HPLC–MS/MS analysis of drugs and metabolites in whole-body thin tissue sections journal, April 2013

Liquid Microjunction Surface Sampling Coupled with High-Pressure Liquid Chromatography−Electrospray Ionization-Mass Spectrometry for Analysis of Drugs and Metabolites in Whole-Body Thin Tissue Sections journal, July 2010

Controlled-Resonant Surface Tapping-Mode Scanning Probe Electrospray Ionization Mass Spectrometry Imaging journal, March 2014

Imaging mass spectrometry of a mouse brain by tapping-mode scanning probe electrospray ionization journal, January 2014

Scanning probe electrospray ionization for ambient mass spectrometry: SPESI for ambient mass spectrometry journal, October 2012

Combining Laser Ablation/Liquid Phase Collection Surface Sampling and High-Performance Liquid Chromatography−Electrospray Ionization-Mass Spectrometry journal, March 2011

Ambient DESI and LESA-MS Analysis of Proteins Adsorbed to a Biomaterial Surface Using In-Situ Surface Tryptic Digestion journal, September 2013

Continuous-flow liquid microjunction surface sampling probe connected on-line with high-performance liquid chromatography/mass spectrometry for spatially resolved analysis of small molecules and proteins: LMJ-SPP on-line with HPLC/MS journal, May 2013

Interface device to couple gel electrophoresis with mass spectrometry using sample disruption patent, May 1993

Method for the ionization of heavy molecules at atmospheric pressure patent, September 1997

Sampling probe for microarray read out using electrospray mass spectrometry patent, October 2004

Combined ambient desorption and ionization source for mass spectrometry patent, December 2008

Pulsed voltage electrospray ion source and method for preventing analyte electrolysis patent, December 2011

Focused analyte spray emission apparatus and process for mass spectrometric analysis patent, January 2012

Ionization source apparatus and method for mass spectrometry patent, July 2012

Method and system for surface sampling patent, December 2012

Spatially resolved thermal desorption/ionization coupled with mass spectrometry patent, February 2013

Surface sampling concentration and reaction probe patent, July 2013

Electrospray ion source with reduced analyte electrochemistry patent, July 2013

Systems and methods for laser assisted sample transfer to solution for chemical analysis patent, August 2013

System and method for laser assisted sample transfer to solution for chemical analysis patent, January 2014

Ionization device, mass spectrometer including the ionization device, and image generation system including the ionization device patent, April 2014

Systems and methods for laser assisted sample transfer to solution for chemical analysis patent, June 2014

AFM fluid delivery/liquid extraction surface sampling/electrostatic spray cantilever probe patent, June 2015

Ionization by Droplet Impact patent-application, May 2006

Mass Spectrometry With Laser Ablation patent-application, June 2008

Enclosed desorption electrospray ionization patent-application, July 2008

Laser desorption - electrospray ion (ESI) source for mass spectrometers patent-application, November 2008

Ionization Method and Apparatus Using Electrospray patent-application, June 2009

System and Method for Extracting a Sample from a Surface patent-application, November 2011

Device for High Spatial Resolution Chemical Analysis of a Sample and Method of High Spatial Resolution Chemical Analysis patent-application, March 2012

Systems and Methods for Laser Assisted Sample Transfer to Solution for Chemical Analysis patent-application, April 2012

Ball Assisted Device for Analytical Surface Sampling patent-application, April 2014

Method and System for Formation and Withdrawal of a Sample from a Surface to be Analyzed patent-application, August 2014

Systems and Methods for Laser Assisted sample Transfer to Solution for Chemical Analysis patent-application, August 2014

Automated liquid microjunction surface sampling-HPLC–MS/MS analysis of drugs and metabolites in whole-body thin tissue sections
journal, April 2013

Liquid Microjunction Surface Sampling Coupled with High-Pressure Liquid Chromatography−Electrospray Ionization-Mass Spectrometry for Analysis of Drugs and Metabolites in Whole-Body Thin Tissue Sections
journal, July 2010

Controlled-Resonant Surface Tapping-Mode Scanning Probe Electrospray Ionization Mass Spectrometry Imaging
journal, March 2014

Imaging mass spectrometry of a mouse brain by tapping-mode scanning probe electrospray ionization
journal, January 2014

Scanning probe electrospray ionization for ambient mass spectrometry: SPESI for ambient mass spectrometry
journal, October 2012

Combining Laser Ablation/Liquid Phase Collection Surface Sampling and High-Performance Liquid Chromatography−Electrospray Ionization-Mass Spectrometry
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Ambient DESI and LESA-MS Analysis of Proteins Adsorbed to a Biomaterial Surface Using In-Situ Surface Tryptic Digestion
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Continuous-flow liquid microjunction surface sampling probe connected on-line with high-performance liquid chromatography/mass spectrometry for spatially resolved analysis of small molecules and proteins: LMJ-SPP on-line with HPLC/MS
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Interface device to couple gel electrophoresis with mass spectrometry using sample disruption
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Method for the ionization of heavy molecules at atmospheric pressure
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Pulsed voltage electrospray ion source and method for preventing analyte electrolysis
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Systems and methods for laser assisted sample transfer to solution for chemical analysis
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