System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis
Abstract
A system for sampling a surface includes a surface sampling probe comprising a solvent liquid supply conduit and a distal end, and a sample collector for suspending a sample collection liquid adjacent to the distal end of the probe. A first electrode provides a first voltage to solvent liquid at the distal end of the probe. The first voltage produces a field sufficient to generate electrospray plume at the distal end of the probe. A second electrode provides a second voltage and is positioned to produce a plume-directing field sufficient to direct the electrospray droplets and ions to the suspended sample collection liquid. The second voltage is less than the first voltage in absolute value. A voltage supply system supplies the voltages to the first electrode and the second electrode. The first electrode can apply the first voltage directly to the solvent liquid. A method for sampling for a surface is also disclosed.
- Inventors:
- Issue Date:
- Research Org.:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1261602
- Patent Number(s):
- 9390901
- Application Number:
- 14/529,307
- Assignee:
- UT-BATTELLE, LLC (Oak Ridge, TN)
- Patent Classifications (CPCs):
-
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- DOE Contract Number:
- AC05-00OR22725
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2014 Oct 31
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 47 OTHER INSTRUMENTATION
Citation Formats
Kertesz, Vilmos, and Van Berkel, Gary J. System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis. United States: N. p., 2016.
Web.
Kertesz, Vilmos, & Van Berkel, Gary J. System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis. United States.
Kertesz, Vilmos, and Van Berkel, Gary J. Tue .
"System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis". United States. https://www.osti.gov/servlets/purl/1261602.
@article{osti_1261602,
title = {System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis},
author = {Kertesz, Vilmos and Van Berkel, Gary J.},
abstractNote = {A system for sampling a surface includes a surface sampling probe comprising a solvent liquid supply conduit and a distal end, and a sample collector for suspending a sample collection liquid adjacent to the distal end of the probe. A first electrode provides a first voltage to solvent liquid at the distal end of the probe. The first voltage produces a field sufficient to generate electrospray plume at the distal end of the probe. A second electrode provides a second voltage and is positioned to produce a plume-directing field sufficient to direct the electrospray droplets and ions to the suspended sample collection liquid. The second voltage is less than the first voltage in absolute value. A voltage supply system supplies the voltages to the first electrode and the second electrode. The first electrode can apply the first voltage directly to the solvent liquid. A method for sampling for a surface is also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {7}
}
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Works referenced in this record:
Automated liquid microjunction surface sampling-HPLC–MS/MS analysis of drugs and metabolites in whole-body thin tissue sections
journal, April 2013
- Kertesz, Vilmos; Van Berkel, Gary J.
- Bioanalysis, Vol. 5, Issue 7
Liquid Microjunction Surface Sampling Coupled with High-Pressure Liquid Chromatography−Electrospray Ionization-Mass Spectrometry for Analysis of Drugs and Metabolites in Whole-Body Thin Tissue Sections
journal, July 2010
- Kertesz, Vilmos; Van Berkel, Gary J.
- Analytical Chemistry, Vol. 82, Issue 14
Controlled-Resonant Surface Tapping-Mode Scanning Probe Electrospray Ionization Mass Spectrometry Imaging
journal, March 2014
- Lorenz, Matthias; Ovchinnikova, Olga S.; Kertesz, Vilmos
- Analytical Chemistry, Vol. 86, Issue 6
Imaging mass spectrometry of a mouse brain by tapping-mode scanning probe electrospray ionization
journal, January 2014
- Otsuka, Yoichi; Naito, Junpei; Satoh, Shuya
- The Analyst, Vol. 139, Issue 10
Scanning probe electrospray ionization for ambient mass spectrometry: SPESI for ambient mass spectrometry
journal, October 2012
- Otsuka, Yoichi; Shide, Sayuri; Naito, Junpei
- Rapid Communications in Mass Spectrometry, Vol. 26, Issue 23
Combining Laser Ablation/Liquid Phase Collection Surface Sampling and High-Performance Liquid Chromatography−Electrospray Ionization-Mass Spectrometry
journal, March 2011
- Ovchinnikova, Olga S.; Kertesz, Vilmos; Van Berkel, Gary J.
- Analytical Chemistry, Vol. 83, Issue 6
Ambient DESI and LESA-MS Analysis of Proteins Adsorbed to a Biomaterial Surface Using In-Situ Surface Tryptic Digestion
journal, September 2013
- Rao, Wei; Celiz, Adam D.; Scurr, David J.
- Journal of The American Society for Mass Spectrometry, Vol. 24, Issue 12
Nanospray desorption electrospray ionization: an ambient method for liquid-extraction surface sampling in mass spectrometry
journal, January 2010
- Roach, Patrick J.; Laskin, Julia; Laskin, Alexander
- The Analyst, Vol. 135, Issue 9
Continuous-flow liquid microjunction surface sampling probe connected on-line with high-performance liquid chromatography/mass spectrometry for spatially resolved analysis of small molecules and proteins: LMJ-SPP on-line with HPLC/MS
journal, May 2013
- Van Berkel, Gary J.; Kertesz, Vilmos
- Rapid Communications in Mass Spectrometry, Vol. 27, Issue 12