Systems and methods for laser assisted sample transfer to solution for chemical analysis

Van Berkel, Gary J.; Kertesz, Vilmos; Ovchinnikova, Olga S.

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Title: Systems and methods for laser assisted sample transfer to solution for chemical analysis

Abstract

Systems and methods are described for laser ablation of an analyte from a specimen and capturing of the analyte in a dispensed solvent to form a testing solution. A solvent dispensing and extraction system can form a liquid microjunction with the specimen. The solvent dispensing and extraction system can include a surface sampling probe. The laser beam can be directed through the surface sampling probe. The surface sampling probe can also serve as an atomic force microscopy probe. The surface sampling probe can form a seal with the specimen. The testing solution including the analyte can then be analyzed using an analytical instrument or undergo further processing.

Inventors:: Van Berkel, Gary J.; Kertesz, Vilmos; Ovchinnikova, Olga S.

Issue Date:: 2015-09-29

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1221973

Patent Number(s):: 9146180

Application Number:: 14/267,482

Assignee:: UT-Battelle, LLC (Oak Ridge, TN)

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G - PHYSICS G01 - MEASURING G01Q - SCANNING-PROBE TECHNIQUES OR APPARATUS

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N1/04 - in the solid state, e.g. by cutting
G01N1/22 - in the gaseous state {
G01N1/38 - Diluting, dispersing or mixing samples
G01N2001/045 - {Laser ablation
G01N2001/383 - {collecting and diluting in a flow of liquid}

G - PHYSICS G01 - MEASURING G01Q - SCANNING-PROBE TECHNIQUES OR APPARATUS
G01Q30/02 - Non-SPM analysing devices, e.g. SEM [Scanning Electron Microscope], spectrometer or optical microscope

H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
H01J49/0463 - {Desorption by laser or particle beam, followed by ionisation as a separate step
H01J49/165 - {Electrospray ionisation}

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DOE Contract Number:: AC05-00OR22725

Resource Type:: Patent

Resource Relation:: Patent File Date: 2014 May 01

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Van Berkel, Gary J., Kertesz, Vilmos, and Ovchinnikova, Olga S. Systems and methods for laser assisted sample transfer to solution for chemical analysis.  United States: N. p., 2015. 
        Web.

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                    Van Berkel, Gary J., Kertesz, Vilmos, & Ovchinnikova, Olga S. Systems and methods for laser assisted sample transfer to solution for chemical analysis.  United States.

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                    Van Berkel, Gary J., Kertesz, Vilmos, and Ovchinnikova, Olga S. Tue .  
        "Systems and methods for laser assisted sample transfer to solution for chemical analysis".  United States.  https://www.osti.gov/servlets/purl/1221973.

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@article{osti_1221973,

  title        = {Systems and methods for laser assisted sample transfer to solution for chemical analysis},

  author       = {Van Berkel, Gary J. and Kertesz, Vilmos and Ovchinnikova, Olga S.},

  abstractNote = {Systems and methods are described for laser ablation of an analyte from a specimen and capturing of the analyte in a dispensed solvent to form a testing solution. A solvent dispensing and extraction system can form a liquid microjunction with the specimen. The solvent dispensing and extraction system can include a surface sampling probe. The laser beam can be directed through the surface sampling probe. The surface sampling probe can also serve as an atomic force microscopy probe. The surface sampling probe can form a seal with the specimen. The testing solution including the analyte can then be analyzed using an analytical instrument or undergo further processing.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2015},

  month        = {9}

}

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Works referenced in this record:

Disposable beverage container
patent, February 1988

Mitri, George
US Patent Document 4,726,487
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4726487

Composite analyzer tester
patent, May 1988

Collins, Richard M.; Chance, Richard F.
US Patent Document 4,745,809
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4745809

Disposable combination cup and base
patent, September 1989

Zimmer, John
US Patent Document 4,865,199
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/4865199

Recyclable corrugated beverage container and holder
patent, April 1993

Coffin, Sr., David W.
US Patent Document 5,205,473
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5205473

Method for selective removal of a material from a wafer's alignment marks
patent, December 1993

Sandhu, Gurtej S.; Laulusa, Alan
US Patent Document 5,271,798
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5271798

Method and apparatus for maldi analysis
patent, July 1998

Hillenkamp, Franz
US Patent Document 5,777,324
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5777324

Method and apparatus for the quantitative measurement of the corrosivity effect of residues present on the surface of electronic circuit assemblies
patent, July 1998

Munson, Terry L.; Pauls, Douglas O.
US Patent Document 5,783,938
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5783938

System and method for on-line coupling of liquid capillary separations with matrix-assisted laser desorption/ionization mass spectrometry
patent, October 2000

Gusev, Arkady I.; Hercules, David M.
US Patent Document 6,140,639
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6140639

Method and apparatus for etch of a specific subarea of a semiconductor work object
patent, September 2001

Morgan, Paul A.; Torek, Kevin J.
US Patent Document 6,290,863
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6290863

Protein crystallization in microfluidic structures
patent, June 2002

Weigl, Bernhard; Sygusch, Jurgen
US Patent Document 6,409,832
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6409832

Miniaturized fluid transfer device
patent, November 2002

Wachs, Timothy; Henion, Jack
US Patent Document 6,478,238
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6478238

Ultra high throughput sampling and analysis systems and methods
patent, September 2003

Wolk, Jeffrey; Biondi, Sherri; Parce, J. Wallace
US Patent Document 6,620,625
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6620625

Sampling probe for microarray read out using electrospray mass spectrometry
patent, October 2004

Van Berkel, Gary J.
US Patent Document 6,803,566
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6803566

Interface members and holders for microfluidic array devices
patent, March 2005

Staats, Sau Lan Tang
US Patent Document 6,864,480
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6864480

Nanotipped device and method
patent, July 2007

Espinosa, Horacio D.; Moldovan, Nicolaie A.; Kim, Keun-Ho
US Patent Document 7,250,139
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7250139

Detection of malaria parasites by mass spectrometry
patent, September 2007

Demirev, Plamen A.; Feldman, Andrew B.; Kongkasuriyachai, Darin
US Patent Document 7,270,948
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7270948

Method for locally highly resolved, mass-spectroscopic characterization of surfaces using scanning probe technology
patent, October 2008

Knebel, Detlef; Amrein, Matthias; Dreisewerd, Klaus
US Patent Document 7,442,922
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7442922

Methods for mass spectrometry detection and quantification of specific target proteins in complex biological samples
patent, November 2008

Everett, Nicholas P.; Petell, James K.; Young, Scott A.
US Patent Document 7,445,907
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7445907

Laser desorption—electrospray ion (ESI) source for mass spectrometers
patent, April 2009

Kovtoun, Viatcheslav V.
US Patent Document 7,525,105
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7525105

Acoustic desorption mass spectrometry
patent, January 2010

Chang, Huan-Cheng; Chen, Chung-Hsuan
US Patent Document 7,645,987
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7645987

Mass spectroscopic reaction-monitoring method
patent, May 2010

Shiea, Jentaie; Yuan, Cheng-Hui; Jheng, Jhih-Yuan
US Patent Document 7,718,958
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7718958

Methods and apparatus for ink delivery to nanolithographic probe systems
patent, July 2010

Cruchon-Dupeyrat, Sylvain; Nelson, Michael; Elghanian, Robert
US Patent Document 7,762,638
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7762638

Mass spectrometry with laser ablation
patent, March 2011

Nikolaev, Evgenij; Franzen, Jochen
US Patent Document 7,910,881
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7910881

Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry
patent, November 2011

Vertes, Akos; Nemes, Peter
US Patent Document 8,067,730
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8067730

Focused analyte spray emission apparatus and process for mass spectrometric analysis
patent, January 2012

Roach, Patrick J.; Laskin, Julia; Laskin, Alexander
US Patent Document 8,097,845
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8097845