PREFERENTIAL INHIBITION OF THE GROWTH OF VIRUS-TRANSFORMED CELLS IN CULTURE BY RIFAZONE-82, A NEW RIFAMYCIN DERIVATIVE

Journal Article · Thu Mar 28 04:00:00 EDT 1974 · Proceedings of the National Academy of Sciences

DOI:https://doi.org/10.1073/pnas.71.6.2520· OSTI ID:939470

Bissell, Mina J; Hatie, Carroll; Tischler, Allan N; Calvin, Melvin

Rifazone-8{sub 2} (R-8{sub 2}), a new rifamycin derivative, is shown to preferentially inhibit the growth of virus-transformed chick cells in culture. Macromolecular synthesis and glucose uptake of transformed cells are also appreciably decreased in the presence of low concentrations of R-8{sub 2} where the normal cells appear unaffected. While R-8{sub 2} is shown to be a selective inhibitor of RNA-directed DNA polymerase in vitro, its action on the growth of transformed cells may involve some other mechanism.

• Research Organization: Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA (US)
• Sponsoring Organization: Life Sciences Division
• DOE Contract Number: AC02-05CH11231
• OSTI ID: 939470
• Report Number(s): LBL-2685
• Journal Information: Proceedings of the National Academy of Sciences, Journal Name: Proceedings of the National Academy of Sciences
• Country of Publication: United States
• Language: English

Related Subjects

99 GENERAL AND MISCELLANEOUS
DNA POLYMERASES
GLUCOSE
IN VITRO
SYNTHESIS