CYTOCIDAL EFFECT OF RIFAMYCIN DERIVATIVES ON ASCITES TUMOR CELLS: STUDIES WITH 125I-IODODEOXYURIDINE
Journal Article
·
· Cancer Letters
OSTI ID:1014065
We have previously reported the chemotherapeutic effect of rifamycin derivatives on an ascites tumor, using increased life span as a criterion. These derivatives inhibit (1) RNA-instructed DNA polymerase in crude viral extracts; (2) virus-induced transformation in tissue cultures; and (3) the growth of tumors in vivo. One rifamycin derivative, rifazone-8{sub 2} (R-8{sub 2}), not only inhibits transformation in chick fibroblasts but affects the growth of transformed cells. The present study demonstrates that rifampicin and R-8{sub 2} act as cytocidal (rather than cytostatic) agents against some ascites cell lines.
- Research Organization:
- Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA (US)
- Sponsoring Organization:
- Chemical Sciences Division
- DOE Contract Number:
- AC02-05CH11231
- OSTI ID:
- 1014065
- Report Number(s):
- LBL-8115
- Journal Information:
- Cancer Letters, Journal Name: Cancer Letters
- Country of Publication:
- United States
- Language:
- English
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