Preferential inhibition of the growth of virus-transformed cells in culture by rifazone-8/sub 2/, a new rifamycin derivative

Journal Article · Sat Jun 01 00:00:00 EDT 1974 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.71.6.2520· OSTI ID:6438290

Bissell, M J; Hatie, C; Tischler, A N; Calvin, M

Rifazone-8/sub 2/, a new rifamycin derivative, is shown to preferentially inhibit the growth of virus-transformed chick cells in culture. Macromolecular synthesis and glucose uptake of transformed cells are also appreciably decreased in the presence of low concentrations of rifazone-8/sub 2/ where the normal cells appear unaffected. While rifazone-8/sub 2/ is shown to be a selective inhibitor of RNA-directed DNA polymerase in vitro, its action on the growth of transformed cells may involve some other mechanism.

• Research Organization: Univ. of California, Berkeley
• OSTI ID: 6438290
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 71:6; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550300* -- Cytology
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMAL CELLS
ANIMALS
BIRDS
CARBOHYDRATES
CELL CULTURES
CHICKENS
DNA
DRUGS
ENZYMES
FOWL
GLUCOSE
GROWTH
HEXOSES
IN VITRO
INHIBITION
MICROORGANISMS
MONOSACCHARIDES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PARASITES
POLYMERASES
RNA
SACCHARIDES
UPTAKE
VERTEBRATES
VIRUSES