Apparatus and method for performing microfluidic manipulations for chemical analysis

Ramsey, J Michael

Apparatus and method for performing microfluidic manipulations for chemical analysis

Patent · Mon Dec 31 23:00:00 EST 2001

OSTI ID:874215

Ramsey, J Michael ^[1]

Knoxville, TN

A microchip apparatus and method provide fluidic manipulations for a variety of applications, including sample injection for microchip liquid chromatography. The microchip is fabricated using standard photolitographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis is performed in channels formed in the substrate. Injections are made by electro-osmotically pumping sample through the injection channel that crosses the separation channel, followed by a switching of the potentials to force a plug into the separation channel.

Research Organization:: LOCKHEED MARTIN ENRGY SYST INC

DOE Contract Number:: AC05-84OR21400

Assignee:: UT-Battelle, LLC (Oak Ridge, TN)

Patent Number(s):: US 6342142

OSTI ID:: 874215

Country of Publication:: United States

Language:: English

References (13)

Towards miniaturized electrophoresis and chemical analysis systems on silicon: an alternative to chemical sensors Harrison, D. Jed; Glavina, P. G.; Manz, Andreas Sensors and Actuators B: Chemical, Vol. 10, Issue 2 https://doi.org/10.1016/0925-4005(93)80033-8	journal	January 1993
Electric sample splitter for capillary zone electrophoresis Deml, M.; Foret, F.; Boček, P. Journal of Chromatography A, Vol. 320, Issue 1 https://doi.org/10.1016/S0021-9673(01)90491-1	journal	February 1985
Planar chips technology for miniaturization and integration of separation techniques into monitoring systems Manz, Andreas; Harrison, D. Jed; Verpoorte, Elisabeth M. J. Journal of Chromatography A, Vol. 593, Issue 1-2 https://doi.org/10.1016/0021-9673(92)80293-4	journal	February 1992
A novel approach to ion separations in solution: synchronized cyclic capillary electrophoresis (SCCE) Burggraf, Norbert; Manz, Andreas; Verpoorte, Elisabeth Sensors and Actuators B: Chemical, Vol. 20, Issue 2-3 https://doi.org/10.1016/0925-4005(93)01200-N	journal	June 1994
High-Speed Separation of Antisense Oligonucleotides on a Micromachined Capillary Electrophoresis Device Effenhauser, Carlo S.; Paulus, Aran.; Manz, Andreas. Analytical Chemistry, Vol. 66, Issue 18 https://doi.org/10.1021/ac00090a024	journal	September 1994
Open Channel Electrochromatography on a Microchip Jacobson, Stephen C.; Hergenroeder, Roland.; Koutny, Lance B. Analytical Chemistry, Vol. 66, Issue 14 https://doi.org/10.1021/ac00086a024	journal	July 1994
Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip Harrison, D. J.; Fluri, K.; Seiler, K. Science, Vol. 261, Issue 5123 https://doi.org/10.1126/science.261.5123.895	journal	August 1993
Electrically Driven Separations on a Microship Jacobsen, S. C.; Gergenroeder, R.; Moore, A. W. 1994 Solid-State, Actuators, and Microsystems Workshop Technical Digest https://doi.org/10.31438/trf.hh1994.15	conference	June 1994
Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices Jacobson, Stephen C.; Hergenroder, Roland.; Koutny, Lance B. Analytical Chemistry, Vol. 66, Issue 7 https://doi.org/10.1021/ac00079a028	journal	April 1994
Capillary electrophoresis and sample injection systems integrated on a planar glass chip Harrison, D. Jed.; Manz, Andreas.; Fan, Zhonghui. Analytical Chemistry, Vol. 64, Issue 17 https://doi.org/10.1021/ac00041a030	journal	September 1992
Synchronized cyclic capillary electrophores—a novel approach to ion separations in solution Burggraf, Norbert; Manz, Andreas; Effenhauser, Carlo S. Journal of High Resolution Chromatography, Vol. 16, Issue 10 https://doi.org/10.1002/jhrc.1240161005	journal	October 1993
Electroosmotic Pumping and Valveless Control of Fluid Flow within a Manifold of Capillaries on a Glass Chip Seiler, Kurt.; Fan, Zhonghui H.; Fluri, Karl. Analytical Chemistry, Vol. 66, Issue 20 https://doi.org/10.1021/ac00092a029	journal	October 1994
Glass chips for high-speed capillary electrophoresis separations with submicrometer plate heights Effenhauser, Carlo S.; Manz, Andreas.; Widmer, H. Michael. Analytical Chemistry, Vol. 65, Issue 19 https://doi.org/10.1021/ac00067a015	journal	October 1993

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/204/422/
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Apparatus and method for performing microfluidic manipulations for chemical analysis

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References (13)

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