Apparatus and method for performing microfluidic manipulations for chemical analysis

Patent · Tue Dec 14 00:00:00 EST 1999

OSTI ID:20013999

Ramsey, J M

A microchip apparatus and method provide fluidic manipulations for a variety of applications, including sample injection for microchip liquid chromatography. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis is performed in channels formed in the substrate. Injections are made by electro-osmotically pumping sample through the injection channel that crosses the separation channel, followed by a switching of the potentials to force a plug into the separation channel.

• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 20013999
• Resource Relation: Other Information: PBD: 14 Dec 1999
• Country of Publication: United States
• Language: English

Related Subjects

40 CHEMISTRY
42 ENGINEERING
LIQUID COLUMN CHROMATOGRAPHY
MATERIALS HANDLING EQUIPMENT
MICROANALYSIS
ELECTROPHORESIS
CAPILLARY FLOW
MICROELECTRONICS
DESIGN
OPERATION