Apparatus and method for performing microfluidic manipulations for chemical analysis

Ramsey, J Michael

Apparatus and method for performing microfluidic manipulations for chemical analysis

Patent · Thu Dec 31 23:00:00 EST 1998

OSTI ID:872745

Ramsey, J Michael ^[1]

Knoxville, TN

A microchip apparatus and method provide fluidic manipulations for a variety of applications, including sample injection for microchip liquid chromatography. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis is performed in channels formed in the substrate. Injections are made by electro-osmotically pumping sample through the injection channel that crosses the separation channel, followed by a switching of the potentials to force a plug into the separation channel.

Research Organization:: LOCKHEED MARTIN ENRGY SYST INC

DOE Contract Number:: AC05-84OR21400

Assignee:: Lockheed Martin Energy Systems, Inc. (Oak Ridge, TN)

Patent Number(s):: US 6001229

OSTI ID:: 872745

Country of Publication:: United States

Language:: English

References (10)

Electroosmosis: A Reliable Fluid Propulsion System for Flow Injection Analysis Dasgupta, Purnendu K.; Liu, Shaorong. Analytical Chemistry, Vol. 66, Issue 11 https://doi.org/10.1021/ac00083a004	journal	June 1994
Electric sample splitter for capillary zone electrophoresis Deml, M.; Foret, F.; Boček, P. Journal of Chromatography A, Vol. 320, Issue 1 https://doi.org/10.1016/S0021-9673(01)90491-1	journal	February 1985
Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip Harrison, D. J.; Fluri, K.; Seiler, K. Science, Vol. 261, Issue 5123 https://doi.org/10.1126/science.261.5123.895	journal	August 1993
Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices Jacobson, Stephen C.; Hergenroder, Roland.; Koutny, Lance B. Analytical Chemistry, Vol. 66, Issue 7 https://doi.org/10.1021/ac00079a028	journal	April 1994
Capillary electrophoresis and sample injection systems integrated on a planar glass chip Harrison, D. Jed.; Manz, Andreas.; Fan, Zhonghui. Analytical Chemistry, Vol. 64, Issue 17 https://doi.org/10.1021/ac00041a030	journal	September 1992
Planar glass chips for capillary electrophoresis: repetitive sample injection, quantitation, and separation efficiency Seiler, Kurt.; Harrison, D. Jed.; Manz, A. Analytical Chemistry, Vol. 65, Issue 10 https://doi.org/10.1021/ac00058a029	journal	May 1993
Micromachining of capillary electrophoresis injectors and separators on glass chips and evaluation of flow at capillary intersections Fan, Zhonghui H.; Harrison, D. Jed. Analytical Chemistry, Vol. 66, Issue 1 https://doi.org/10.1021/ac00073a029	journal	January 1994
Micromachining of monocrystalline silicon and glass for chemical analysis systems A look into next century's technology or just a fashionable craze? Manz, A.; Fettinger, J. C.; Verpoorte, E. TrAC Trends in Analytical Chemistry, Vol. 10, Issue 5 https://doi.org/10.1016/0165-9936(91)85116-9	journal	May 1991
High-Speed Separations on a Microchip Jacobson, Stephen C.; Hergenroder, Roland.; Koutny, Lance B. Analytical Chemistry, Vol. 66, Issue 7 https://doi.org/10.1021/ac00079a029	journal	April 1994
Glass chips for high-speed capillary electrophoresis separations with submicrometer plate heights Effenhauser, Carlo S.; Manz, Andreas.; Widmer, H. Michael. Analytical Chemistry, Vol. 65, Issue 19 https://doi.org/10.1021/ac00067a015	journal	October 1993

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Related Subjects

/204/
analysis
apparatus
applications
bonding
capillary
capillary electrophoresis
channel
channels
channels formed
chemical
chemical analysis
chemical wet
chromatography
cover
cover plate
crosses
direct
direct bonding
electro-osmotically
electrophoresis
etching
fabricated
fluidic
fluidic manipulations
followed
force
formed
including
including sample
injection
injections
joined
liquid
liquid chromatograph
liquid chromatography
lithographic procedures
manipulations
method
method provide
microchip
microfluidic
microfluidic manipulations
performed
performing
performing microfluidic
photolithographic
photolithographic procedures
plate
plate joined
plug
potentials
procedures
provide
provide fluid
pumping
sample
sample injection
separation
separation channel
standard
standard photolithographic
substrate
switching
variety
wet
wet etching

Apparatus and method for performing microfluidic manipulations for chemical analysis

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References (10)

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