Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis

Patent · 12 January 1999

OSTI ID:321255

Ramsey, J M

A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel. 46 figs.

• Research Organization: Lockheed Martin Energy Syst Inc
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: AC05-84OR21400
• Assignee: Lockheed Martin Energy Research Corp., Oak Ridge, TN (United States)
• Patent Number(s): US 5,858,195/A/
• Application Number: PAN: 8-776,645
• OSTI ID: 321255
• Country of Publication: United States
• Language: English

Related Subjects

40 CHEMISTRY
42 ENGINEERING
CHROMATOGRAPHY
DESIGN
ELECTROPHORESIS
MATERIALS HANDLING
MICROELECTRONICS
MINIATURIZATION
SAMPLE HOLDERS