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Title: Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis

Patent ·
OSTI ID:321255

A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel. 46 figs.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE, Washington, DC (United States)
DOE Contract Number:
AC05-84OR21400
Assignee:
Lockheed Martin Energy Research Corp., Oak Ridge, TN (United States)
Patent Number(s):
US 5,858,195/A/
Application Number:
PAN: 8-776,645
OSTI ID:
321255
Resource Relation:
Other Information: PBD: 12 Jan 1999
Country of Publication:
United States
Language:
English