Stimulus sensitive gel with radioisotope and methods of making

Weller, Richard E; Lind, Michael A; Fisher, Darrell R; Gutowska, Anna; Campbell, Allison A

Stimulus sensitive gel with radioisotope and methods of making

Patent · Tue Oct 02 04:00:00 EDT 2001

OSTI ID:874026

Weller, Richard E ^[1]; Lind, Michael A ^[2]; Fisher, Darrell R ^[3]; Gutowska, Anna ^[3]; Campbell, Allison A ^[4]

Selah, WA
Kent, WA
Richland, WA
Kennewick, WA

The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC06-76RL01830

Assignee:: Battelle Memorial Institute (Richland, WA)

Patent Number(s):: US 6296831

Application Number:: 09/058,712

OSTI ID:: 874026

Country of Publication:: United States

Language:: English

References (12)

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acrylamide
acrylamide derivative
addition
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aqueous
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backbone
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carrier
chains
combining
comonomer
copolymer
cutoff
derivative
enhanced
equal
form
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hydrophilic
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linear
linear random
method
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minimum
mixing
molecular
molecular weight
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solution
solvent
steps
stimulus
stimulus-sensitive
therapeutic
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Stimulus sensitive gel with radioisotope and methods of making

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References (12)

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