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Stimulus sensitive gel with radioisotope and methods of making

Patent ·
OSTI ID:1175283
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The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.
Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC06-76RL01830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
6,869,588
Application Number:
09/853,507
OSTI ID:
1175283
Country of Publication:
United States
Language:
English

References (12)

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Gelation of globular proteins: effect of pH and ionic strength on the critical concentration for gel formation. A simple model and its application to β-lactoglobulin heat-induced gelation journal October 1992
Lower Critical Solution Temperatures of Aqueous Copolymers of N-Isopropylacrylamide and Other N-Substituted Acrylamides book September 1987
Intelligent Gels journal May 1993
Synthesis and characterization of the gadolinium(3+) complex of DOTA-propylamide: a model DOTA-protein conjugate journal February 1989
Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH journal January 1995
Superporous Hydrogels: fast Responsive Hydrogel Systems journal January 1999
Intratumoral radioimmunotherapy of a human colon cancer xenograft using a sustained-release gel journal May 1996
Thermally reversible polymer gels for biohybrid artificial pancreas journal May 1996
Phase transitions in crosslinked gels of natural polymers journal September 1987
Copper chelates as probes of biological systems: Stable copper complexes with a macrocyclic bifunctional chelating agent journal July 1985

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36 MATERIALS SCIENCE