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Reversible geling co-polymer and method of making

Patent ·
OSTI ID:1175593
The present invention is a thereapeutic agent carrier having a thermally reversible gel or geling copolymer that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum geling molecular weight cutoff and a therapeutic agent.
Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC06-76RL01830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
6,979,464
Application Number:
09/209,541
OSTI ID:
1175593
Country of Publication:
United States
Language:
English

References (19)

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Temperature- and pH-sensitive terpolymers for modulated delivery of streptokinase journal January 1997
Swelling equilibria for weakly ionizable, temperature-sensitive hydrogels journal March 1991
Temperature-modulated platelet and lymphocyte interactions with poly(N-isopropylacrylamide)-grafted surfaces journal January 1995
A new temperature- and pH-responsive copolymer for possible use in protein conjugation journal April 1995
Conjugates of stimuli-responsive polymers and biomolecules: Random and site-specific conjugates of temperature-sensitive polymers and proteins journal June 1997
Lower Critical Solution Temperatures of Aqueous Copolymers of N-Isopropylacrylamide and Other N-Substituted Acrylamides book September 1987
Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH journal January 1995
Effect of temperature cycling on the activity and productivity of immobilized β-galactosidase in a thermally reversible hydrogel bead reactor journal October 1988
Synthesis of macroporous hydrogels with rapid swelling and deswelling properties for delivery of macromolecules journal January 1995
Biodegradable block copolymers as injectable drug-delivery systems journal August 1997
Thermally reversible polymer gels for biohybrid artificial pancreas journal May 1996
“Intelligent” Polymers in Medicine and Biotechnology journal May 1995
Effect of comonomer hydrophilicity and ionization on the lower critical solution temperature of N-isopropylacrylamide copolymers journal May 1993
Temperature- and pH- Sensitive Hydrogels for Controlled Release of Antithrombotic Agents journal January 1993
Immobilization and characterization of ?-galactosidase in thermally reversible hydrogel beads journal January 1990
Temperature-responsive poly(N-isopropylacrylamide) as a modulator for alteration of hydrophilic/hydrophobic surface properties to control activation/inactivation of platelets journal September 1995
Inverse thermally-reversible gelation of aqueous N-isopropylacrylamide copolymer solutions journal June 1998

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Related Subjects

36 MATERIALS SCIENCE