Capillary electrophoresis electrospray ionization mass spectrometry interface
Patent
·
OSTI ID:872700
- Richland, WA
- Hayward, CA
The present invention is an interface between a capillary electrophoresis separation capillary end and an electrospray ionization mass spectrometry emitter capillary end, for transporting an anolyte sample from a capillary electrophoresis separation capillary to a electrospray ionization mass spectrometry emitter capillary. The interface of the present invention has: (a) a charge transfer fitting enclosing both of the capillary electrophoresis capillary end and the electrospray ionization mass spectrometry emitter capillary end; (b) a reservoir containing an electrolyte surrounding the charge transfer fitting; and (c) an electrode immersed into the electrolyte, the electrode closing a capillary electrophoresis circuit and providing charge transfer across the charge transfer fitting while avoiding substantial bulk fluid transfer across the charge transfer fitting. Advantages of the present invention have been demonstrated as effective in providing high sensitivity and efficient analyses.
- Research Organization:
- BATTELLE MEMORIAL INSTITUTE
- DOE Contract Number:
- AC06-76RL01830
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Number(s):
- US 5993633
- OSTI ID:
- 872700
- Country of Publication:
- United States
- Language:
- English
Use of heptakis(2,6-di-O-methyl)-β-cyclodextrin in on-line capillary zone electrophoresis-mass spectrometry for the chiral separation of ropivacaine
|
journal | August 1996 |
On-line coupling of micellar electrokinetic chromatography to electrospray mass spectrometry
|
journal | September 1995 |
Liquid junction coupling for capillary zone electrophoresis/ion spray mass spectrometry
|
journal | September 1989 |
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Related Subjects
/204/250/
advantages
analyses
anolyte
avoiding
bulk
capillary
capillary electrophoresis
charge
charge transfer
circuit
closing
containing
demonstrated
effective
efficient
electrode
electrolyte
electrophoresis
electrophoresis separation
electrospray
electrospray ionization
emitter
enclosing
fitting
fluid
fluid transfer
immersed
interface
ionization
ionization mass
mass
mass spectrometry
providing
reservoir
reservoir containing
sample
sensitivity
separation
spectrometry
spectrometry interface
substantial
substantial bulk
surrounding
transfer
transporting
advantages
analyses
anolyte
avoiding
bulk
capillary
capillary electrophoresis
charge
charge transfer
circuit
closing
containing
demonstrated
effective
efficient
electrode
electrolyte
electrophoresis
electrophoresis separation
electrospray
electrospray ionization
emitter
enclosing
fitting
fluid
fluid transfer
immersed
interface
ionization
ionization mass
mass
mass spectrometry
providing
reservoir
reservoir containing
sample
sensitivity
separation
spectrometry
spectrometry interface
substantial
substantial bulk
surrounding
transfer
transporting