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Title: Capillary electrophoresis electrospray ionization mass spectrometry interface

Abstract

The present invention is an interface between a capillary electrophoresis separation capillary end and an electrospray ionization mass spectrometry emitter capillary end, for transporting an anolyte sample from a capillary electrophoresis separation capillary to a electrospray ionization mass spectrometry emitter capillary. The interface of the present invention has: (a) a charge transfer fitting enclosing both of the capillary electrophoresis capillary end and the electrospray ionization mass spectrometry emitter capillary end; (b) a reservoir containing an electrolyte surrounding the charge transfer fitting; and (c) an electrode immersed into the electrolyte, the electrode closing a capillary electrophoresis circuit and providing charge transfer across the charge transfer fitting while avoiding substantial bulk fluid transfer across the charge transfer fitting. Advantages of the present invention have been demonstrated as effective in providing high sensitivity and efficient analyses.

Inventors:
 [1];  [2]
  1. Richland, WA
  2. Hayward, CA
Publication Date:
Research Org.:
Battelle Memorial Institute, Columbus, OH (United States)
OSTI Identifier:
872700
Patent Number(s):
US 5993633
Assignee:
Battelle Memorial Institute (Richland, WA)
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
capillary; electrophoresis; electrospray; ionization; mass; spectrometry; interface; separation; emitter; transporting; anolyte; sample; charge; transfer; fitting; enclosing; reservoir; containing; electrolyte; surrounding; electrode; immersed; closing; circuit; providing; avoiding; substantial; bulk; fluid; advantages; demonstrated; effective; sensitivity; efficient; analyses; ionization mass; electrospray ionization; capillary electrophoresis; mass spectrometry; charge transfer; substantial bulk; reservoir containing; electrophoresis separation; fluid transfer; spectrometry interface; /204/250/

Citation Formats

Smith, Richard D, and Severs, Joanne C. Capillary electrophoresis electrospray ionization mass spectrometry interface. United States: N. p., 1999. Web.
Smith, Richard D, & Severs, Joanne C. Capillary electrophoresis electrospray ionization mass spectrometry interface. United States.
Smith, Richard D, and Severs, Joanne C. 1999. "Capillary electrophoresis electrospray ionization mass spectrometry interface". United States. https://www.osti.gov/servlets/purl/872700.
@article{osti_872700,
title = {Capillary electrophoresis electrospray ionization mass spectrometry interface},
author = {Smith, Richard D and Severs, Joanne C},
abstractNote = {The present invention is an interface between a capillary electrophoresis separation capillary end and an electrospray ionization mass spectrometry emitter capillary end, for transporting an anolyte sample from a capillary electrophoresis separation capillary to a electrospray ionization mass spectrometry emitter capillary. The interface of the present invention has: (a) a charge transfer fitting enclosing both of the capillary electrophoresis capillary end and the electrospray ionization mass spectrometry emitter capillary end; (b) a reservoir containing an electrolyte surrounding the charge transfer fitting; and (c) an electrode immersed into the electrolyte, the electrode closing a capillary electrophoresis circuit and providing charge transfer across the charge transfer fitting while avoiding substantial bulk fluid transfer across the charge transfer fitting. Advantages of the present invention have been demonstrated as effective in providing high sensitivity and efficient analyses.},
doi = {},
url = {https://www.osti.gov/biblio/872700}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {1}
}

Works referenced in this record:

On-line coupling of micellar electrokinetic chromatography to electrospray mass spectrometry
journal, September 1995


Liquid junction coupling for capillary zone electrophoresis/ion spray mass spectrometry
journal, September 1989