Capillary electrophoresis electrospray ionization mass spectrometry interface
- Richland, WA
- Hayward, CA
The present invention is an interface between a capillary electrophoresis separation capillary end and an electrospray ionization mass spectrometry emitter capillary end, for transporting an anolyte sample from a capillary electrophoresis separation capillary to a electrospray ionization mass spectrometry emitter capillary. The interface of the present invention has: (a) a charge transfer fitting enclosing both of the capillary electrophoresis capillary end and the electrospray ionization mass spectrometry emitter capillary end; (b) a reservoir containing an electrolyte surrounding the charge transfer fitting; and (c) an electrode immersed into the electrolyte, the electrode closing a capillary electrophoresis circuit and providing charge transfer across the charge transfer fitting while avoiding substantial bulk fluid transfer across the charge transfer fitting. Advantages of the present invention have been demonstrated as effective in providing high sensitivity and efficient analyses.
- Research Organization:
- Battelle Memorial Institute, Columbus, OH (United States)
- DOE Contract Number:
- AC06-76RL01830
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Number(s):
- US 5993633
- OSTI ID:
- 872700
- Country of Publication:
- United States
- Language:
- English
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journal | September 1995 |
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Related Subjects
electrophoresis
electrospray
ionization
mass
spectrometry
interface
separation
emitter
transporting
anolyte
sample
charge
transfer
fitting
enclosing
reservoir
containing
electrolyte
surrounding
electrode
immersed
closing
circuit
providing
avoiding
substantial
bulk
fluid
advantages
demonstrated
effective
sensitivity
efficient
analyses
ionization mass
electrospray ionization
capillary electrophoresis
mass spectrometry
charge transfer
substantial bulk
reservoir containing
electrophoresis separation
fluid transfer
spectrometry interface
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