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Title: Mutation assays involving blood cells that metabolize toxic substances

Patent ·
OSTI ID:872440
 [1];  [2]
  1. Marblehead, MA
  2. Winchester, MA
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The present invention pertains to a line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity). Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. The invention also includes mutation assays using these cells, and other cells with similar characteristics.

Research Organization:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
DOE Contract Number:
AC04-76
Assignee:
Massachusetts Institute of Technology (Cambridge, MA)
Patent Number(s):
US 5935829
OSTI ID:
872440
Country of Publication:
United States
Language:
English

References (3)

Definition of conditions for the detection of genotoxic chemicals in the adult rat-liver epithelial cell/hypoxanthine—guanine phosphoribosyl transferase (ARL/HGRPT) mutagenesis assay journal February 1980
Differences in responses of 4 adult rat-liver epithelial cell lines to a spectrum of chemical mutagens journal February 1984
Induction of purine analog-resistant mutants in adult rat liver epithelial lines by metabolic activation-dependent and -independent carcinogens journal November 1978

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human
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oxidative
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oxygenase
oxidase
peroxidase
hydroxylase
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xenobiotic
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blood cells
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