Mutation assays involving blood cells that metabolize toxic substances
Patent
·
OSTI ID:678583
The present invention pertains to a line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity). Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. The invention also includes mutation assays using these cells, and other cells with similar characteristics. 3 figs.
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- Assignee:
- Massachusetts Inst. of Tech., Cambridge, MA (United States)
- Patent Number(s):
- US 5,935,829/A/
- Application Number:
- PAN: 7-817,971
- OSTI ID:
- 678583
- Country of Publication:
- United States
- Language:
- English
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