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Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites

Patent ·
OSTI ID:872369
 [1];  [2]
  1. Atlanta, GA
  2. Lithonia, GA
+ Show Author Affiliations
Halogenated naphthyl methoxy piperidines having a strong affinity for the serotonin transporter are disclosed. Those compounds can be labeled with positron-emitting and/or gamma emitting halogen isotopes by a late step synthesis that maximizes the useable lifeterm of the label. The labeled compounds are useful for localizing serotonin transporter sites by positron emission tomography and/or single photon emission computed tomography.
Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN
DOE Contract Number:
FG05-93ER61737
Assignee:
Emory University (Atlanta, GA)
Patent Number(s):
US 5919797
OSTI ID:
872369
Country of Publication:
United States
Language:
English

References (10)

In vivo imaging of the 5-hydroxytryptamine reuptake site in primate brain using single photon emission computed tomography and [123I]5-iodo-6-nitroquipazine journal September 1993
Radiosynthesis and evaluation of N-(3-[18F]fluoropropyl)paroxetine as a radiotracer for in vivo labeling of serotonin uptake sites by PET
  • Suehiro, Makiko; Wilson, Alan A.; Scheffel, Ursula
  • International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 18, Issue 7 https://doi.org/10.1016/0883-2897(91)90019-H
journal January 1991
Evaluation of [3H]paroxetine as an in vivo ligand for serotonin uptake sites: A quantitative autoradiographic study in the rat brain journal January 1993
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships journal August 1987
[125I]5-iodo-6-nitroquipazine: a potent and selective ligand for the 5-hydroxytrrptamine uptake complex. II. In vivo studies in rats journal August 1993
Citalopram: Labelling with carbon-11 and evaluation in rat as a potential radioligand for in vivo PET studies of 5-HT re-uptake sites journal January 1991
SL 81.0385: A novel selective and potent serotonin uptake inhibitor journal January 1988
Synthesis of radiolabeled inhibitors of presynaptic monoamine uptake systems; [18F]GBR 13119 (DA),[11C]nisoxetine (NE), and [11C]fluoxetine (5-HT) journal January 1989
Synthesis, in vivo biodistribution and dosimetry of [11C]N-Methylpiperidyl benzilate ([11C]NMPB), a muscarinic acetylcholine receptor antagonist journal January 1995
Synthesis of 123I-and labelled 5-iodo-6-nitroquipazine journal October 1994

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Related Subjects

/514/424/999/
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