Labeled Cocaine Analogs

Patent · Tue Mar 30 04:00:00 EST 1999

OSTI ID:879462

Goodman, Mark M ^[1]; Shi, Bing Zhi ^[2]; Keil, Robert N ^[1]

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1. Atlanta, GA
2. Tucker, GA

Novel methods for positron emission tomography or single photon emission spectroscopy using tracer compounds having the structure: ##STR1## where X in .beta. configuration is phenyl, naphthyl; 2,3 or 4-iodophenyl; 2,3 or 4-(trimethylsilyl)phenyl; 3,4,5 or 6-iodonaphthyl; 3,4,5 or 6-(trimethylsilyl)naphthyl; 2,3 or 4-(trialkylstannyl)phenyl; or 3,4,5 or 6-(trialkylstannyl)napthyl Y in .beta. configuration is 2-fluoroethoxy, 3-fluoropropoxy, 4-fluorobutoxy, 2-fluorocyclopropoxy, 2 or 3-fluorocyclobutoxy, R,S 1'-fluoroisopropoxy, R 1'-fluoroisopropoxy, S 1'-fluoroisopropoxy, 1',3'-difluoroisopropoxy, R,S 1'-fluoroisobutoxy, R 1'-fluoroisobutoxy, S 1'-fluoroisobutoxy, R,S 4'-fluoroisobutoxy, R 4'-fluoroisobutoxy, S 4'-fluoroisobutoxy, or 1',1'-di(fluoromethyl)isobutoxy, The compounds bind dopamine transporter protein and can be labeled with .sup.18 F or .sup.123 I for imaging.

• Research Organization: Emory University (Atlanta, GA)
• DOE Contract Number: FG05-93ER61737
• Assignee: Emory University (Atlanta, GA)
• Patent Number(s): US 5,888,475
• Application Number: 08/948791
• OSTI ID: 879462
• Country of Publication: United States
• Language: English