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Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites

Patent ·
OSTI ID:6298489
;
Halogenated naphthyl methoxy piperidines having a strong affinity for the serotonin transporter are disclosed. Those compounds can be labeled with positron-emitting and/or gamma emitting halogen isotopes by a late step synthesis that maximizes the useable lifeterm of the label. The labeled compounds are useful for localizing serotonin transporter sites by positron emission tomography and/or single photon emission computed tomography.
Sponsoring Organization:
DOE; USDOE, Washington, DC (United States)
DOE Contract Number:
FG05-93ER61737
Assignee:
Emory Univ., Atlanta, GA (United States)
Patent Number(s):
A; US 5919797
Application Number:
PPN: US 8-840651
OSTI ID:
6298489
Country of Publication:
United States
Language:
English

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Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
AFFINITY
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZINES
AZOLES
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
LABELLING
MEMBRANE PROTEINS
MEMBRANE TRANSPORT
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIPERIDINES
PROTEINS
PYRIDINES
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RECEPTORS
SEROTONIN
SYMPATHOMIMETICS
TRYPTAMINES