Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites

Patent · Tue Jul 06 00:00:00 EDT 1999

OSTI ID:6298489

Goodman, M M; Faraj, B

Halogenated naphthyl methoxy piperidines having a strong affinity for the serotonin transporter are disclosed. Those compounds can be labeled with positron-emitting and/or gamma emitting halogen isotopes by a late step synthesis that maximizes the useable lifeterm of the label. The labeled compounds are useful for localizing serotonin transporter sites by positron emission tomography and/or single photon emission computed tomography.

• Sponsoring Organization: USDOE; USDOE, Washington, DC (United States)
• DOE Contract Number: FG05-93ER61737
• Assignee: Emory Univ., Atlanta, GA (United States)
• Patent Number(s): US 5919797; A
• Application Number: PPN: US 8-840651
• OSTI ID: 6298489
• Resource Relation: Patent File Date: 24 Apr 1997
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
AFFINITY
LABELLING
MEMBRANE TRANSPORT
PIPERIDINES
RECEPTORS
SEROTONIN
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZINES
AZOLES
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
MEMBRANE PROTEINS
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROTEINS
PYRIDINES
PYRROLES
RADIOPROTECTIVE SUBSTANCES
SYMPATHOMIMETICS
TRYPTAMINES
550200* - Biochemistry