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Cyanine dyes with high-absorbance cross section as donor chromophores in energy transfer labels

Patent ·
OSTI ID:872064
 [1];  [2];  [3];  [4]
  1. Orinda, CA
  2. Moraga, CA
  3. Richmond, CA
  4. Redwood City, CA
+ Show Author Affiliations

Cyanine dyes are used as the donor fluorophore in energy transfer labels in which light energy is absorbed by a donor fluorophore and transferred to an acceptor fluorophore which responds to the transfer by emitting fluorescent light for detection. The cyanine dyes impart an unusually high sensitivity to the labels thereby improving their usefulness in a wide variety of biochemical procedures, particularly nucleic acid sequencing, nucleic acid fragment sizing, and related procedures.

Research Organization:
University of California
DOE Contract Number:
FG03-91ER61125
Assignee:
Regents of University of California (Oakland, CA)
Patent Number(s):
US 5853992
OSTI ID:
872064
Country of Publication:
United States
Language:
English

References (4)

Cyanine Dyes with High Absorption Cross Section as Donor Chromophores in Energy Transfer Primers1 journal December 1996
Design and Synthesis of Fluorescence Energy Transfer Dye-Labeled Primers and Their Application for DNA Sequencing and Analysis journal October 1995
Rapid Sizing of Short Tandem Repeat Alleles Using Capillary Array Electrophoresis and Energy-Transfer Fluorescent Primers journal April 1995
Energy Transfer Primers with 5- or 6-Carboxyrhodamine-6G as Acceptor Chromophores journal July 1996

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