Probes labelled with energy transfer coupled dyes

Mathies, Richard A; Glazer, Alexander; Ju, Jingyue

Probes labelled with energy transfer coupled dyes

Patent · Tue Dec 31 23:00:00 EST 1996

OSTI ID:871235

Mathies, Richard A ^[1]; Glazer, Alexander ^[2]; Ju, Jingyue ^[3]

El Cerrito, CA
Orinda, CA
Berkeley, CA

Compositions are provided comprising sets of fluorescent labels carrying pairs of donor and acceptor dye molecules, designed for efficient excitation of the donors at a single wavelength and emission from the acceptor in each of the pairs at different wavelengths. The different molecules having different donor-acceptor pairs can be modified to have substantially the same mobility under separation conditions, by varying the distance between the donor and acceptor in a given pair. Particularly, the fluorescent compositions find use as labels in sequencing nucleic acids.

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Research Organization:: University of California

DOE Contract Number:: FG03-91ER61125

Assignee:: Regents of University of California (Oakland, CA)

Patent Number(s):: US 5688648

OSTI ID:: 871235

Country of Publication:: United States

Language:: English

References (22)

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Probes labelled with energy transfer coupled dyes

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