Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging

Patent · Tue Jun 03 00:00:00 EDT 1997

OSTI ID:870978

Mease, Ronnie C ^[1]; Kolsky, Kathryn L ^[2]; Mausner, Leonard F ^[3]; Srivastava, Suresh C ^[4]

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1. 2101 B. Ulster Pl., Coram, NY 11727
2. 460 Harrison Ave., Miller Pl., NY 11764
3. 16 Seville Ln., Stony Brook, NY 11790
4. 8 Penelope Dr., Setauket, NY 11733

Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.

• Research Organization: ASSOC UNIVERSITIES INC
• DOE Contract Number: AC02-76CH00016
• Assignee: Mease, Ronnie C. (2101 B. Ulster Pl., Coram, NY 11727);Kolsky, Kathryn L. (460 Harrison Ave., Miller Pl., NY 11764);Mausner, Leonard F. (16 Seville Ln., Stony Brook, NY 11790);Srivastava, Suresh C. (8 Penelope Dr., Setauket, NY 11733)
• Patent Number(s): US 5635157
• Application Number: 08/132,201
• OSTI ID: 870978
• Country of Publication: United States
• Language: English

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2-diamino
2-diaminocyclohexyl
4-haloacetamido-trans-1
4-isothiocyanato-trans-1
4-substituted-trans-1
acetic
acetic acid
acid
agents
agents useful
antibody
antibody immunoconjugates
antibody-metal
chelating
chelating agent
chelating agents
compounds
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cyclohexane-n
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forming antibody-metal
imaging
immunoconjugates
including
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polyaminocarboxylate
polyaminocarboxylate metal
preparation
processes
purposes
radiometal
radiometal antibody
spect
stable
stable radiometal
synthesis
therapeutic
therapeutic purposes
therapy
useful