Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and SPECT and PET imaging

Patent · Tue Mar 08 00:00:00 EST 1994

OSTI ID:5043183

Mease, R C; Mausner, L F; Srivastava, S C

Cyclo agents are described which are useful in forming antibody-metal conjugates which are used for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2diamino cyclohexane-N,N,N',N'-tetra acetic acid. No Drawings

• DOE Contract Number: AC02-76CH00016
• Assignee: Associated Universities, Inc., Washington, DC (United States)
• Patent Number(s): US 5292938; A
• Application Number: PPN: US 7-867533
• OSTI ID: 5043183
• Resource Relation: Patent File Date: 13 Apr 1992
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CHELATING AGENTS
CHEMICAL PREPARATION
EMISSION COMPUTED TOMOGRAPHY
RADIOIMMUNOASSAY
RADIOIMMUNOTHERAPY
RADIOPHARMACEUTICALS
BIOASSAY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
IMMUNOASSAY
IMMUNOTHERAPY
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MEDICINE
NUCLEAR MEDICINE
RADIOASSAY
RADIOIMMUNODETECTION
RADIOLOGY
RADIOTHERAPY
SYNTHESIS
THERAPY
TOMOGRAPHY
TRACER TECHNIQUES
550601* - Medicine- Unsealed Radionuclides in Diagnostics