Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
Patent
·
OSTI ID:870978
- 2101 B. Ulster Pl., Coram, NY 11727
- 460 Harrison Ave., Miller Pl., NY 11764
- 16 Seville Ln., Stony Brook, NY 11790
- 8 Penelope Dr., Setauket, NY 11733
Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.
- Research Organization:
- Associated Universities, Inc., Upton, NY (United States)
- DOE Contract Number:
- AC02-76CH00016
- Assignee:
- Mease, Ronnie C. (2101 B. Ulster Pl., Coram, NY 11727);Kolsky, Kathryn L. (460 Harrison Ave., Miller Pl., NY 11764);Mausner, Leonard F. (16 Seville Ln., Stony Brook, NY 11790);Srivastava, Suresh C. (8 Penelope Dr., Setauket, NY 11733)
- Patent Number(s):
- US 5635157
- Application Number:
- 08/132,201
- OSTI ID:
- 870978
- Country of Publication:
- United States
- Language:
- English
Preface
|
journal | December 1993 |
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Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and SPECT and PET imaging
Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and SPECT and PET imaging
Patent
·
Tue Jun 03 00:00:00 EDT 1997
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OSTI ID:870978
+1 more
Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
Patent
·
Sat Jan 01 00:00:00 EST 1994
·
OSTI ID:870978
Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and SPECT and PET imaging
Patent
·
Tue Mar 08 00:00:00 EST 1994
·
OSTI ID:870978
Related Subjects
synthesis
4-substituted-trans-1
2-diaminocyclohexyl
polyaminocarboxylate
metal
chelating
agents
preparation
stable
radiometal
antibody
immunoconjugates
therapy
spect
pet
imaging
cyclohexyl
useful
forming
antibody-metal
conjugates
diagnostic
therapeutic
purposes
compounds
processes
disclosed
including
4-haloacetamido-trans-1
4-isothiocyanato-trans-1
2-diamino
cyclohexane-n
-tetra
acetic
acid
therapeutic purposes
metal chelating
stable radiometal
radiometal antibody
acetic acid
chelating agents
chelating agent
disclosed including
pet imaging
antibody immunoconjugates
agents useful
cyclohexyl polyaminocarboxylate
forming antibody-metal
polyaminocarboxylate metal
/424/530/999/
4-substituted-trans-1
2-diaminocyclohexyl
polyaminocarboxylate
metal
chelating
agents
preparation
stable
radiometal
antibody
immunoconjugates
therapy
spect
pet
imaging
cyclohexyl
useful
forming
antibody-metal
conjugates
diagnostic
therapeutic
purposes
compounds
processes
disclosed
including
4-haloacetamido-trans-1
4-isothiocyanato-trans-1
2-diamino
cyclohexane-n
-tetra
acetic
acid
therapeutic purposes
metal chelating
stable radiometal
radiometal antibody
acetic acid
chelating agents
chelating agent
disclosed including
pet imaging
antibody immunoconjugates
agents useful
cyclohexyl polyaminocarboxylate
forming antibody-metal
polyaminocarboxylate metal
/424/530/999/