Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices

Karger, Barry L; Thilly, William G; Foret, Frantisek; Khrapko, Konstaintin; Koehavong, Phouthone; Cohen, Aharon S; Giese, Roger W

Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices

Patent · Tue Dec 31 23:00:00 EST 1996

OSTI ID:870968

Karger, Barry L ^[1]; Thilly, William G ^[2]; Foret, Frantisek ^[3]; Khrapko, Konstaintin ^[4]; Koehavong, Phouthone ^[5]; Cohen, Aharon S ^[1]; Giese, Roger W ^[6]

Newton, MA
Winchester, MA
Malden, MA
Brookline, MA
Pittsburgh, PA
Quincy, MA

The disclosure relates to a method for resolving double-stranded DNA species differing by at least one base pair. Each of the species is characterized by an iso-melting domain with a unique melting temperature contiguous with a melting domain of higher thermal stability.

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Research Organization:: Massachusetts Institute of Technology (Cambridge, MA)

DOE Contract Number:: FG02-86ER60448

Assignee:: Massachusetts Institute of Technology (Cambridge, MA); Northeastern University (Boston, MA)

Patent Number(s):: US 5633129

OSTI ID:: 870968

Country of Publication:: United States

Language:: English

References (22)

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Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices

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