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Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices

Patent ·
OSTI ID:489097

The disclosure relates to a method for resolving double-stranded DNA species differing by at least one base pair. Each of the species is characterized by an iso-melting domain with a unique melting temperature contiguous with a melting domain of higher thermal stability. 18 figs.

Sponsoring Organization:
National Inst. of Environmental Health Sciences, Research Triangle Park, NC (United States); USDOE, Washington, DC (United States)
Assignee:
Massachusetts Inst. of Tech., Cambridge, MA (United States); Northeastern Univ., Boston, MA (United States)
Patent Number(s):
US 5,633,129/A/
Application Number:
PAN: 8-190,919
OSTI ID:
489097
Country of Publication:
United States
Language:
English