Method for protection against genotoxic mutagenesis

Grdina, David J

Method for protection against genotoxic mutagenesis

Patent · Mon Jan 01 04:00:00 EST 1996

OSTI ID:870650

Grdina, David J ^[1]

Naperville, IL

A method and pharmaceutical for protecting against mutational damage in mammalian cells, irrespective of the nature of the mutagenic event or source of radiational or chemical insult or the like.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL

DOE Contract Number:: W-31109-ENG-38

Assignee:: Arch Development Corporation (Chicago, IL)

Patent Number(s):: US 5567686

OSTI ID:: 870650

Country of Publication:: United States

Language:: English

References (26)

Differential Effects of Radical Scavengers on X-Ray-Induced Mutation and Cytotoxicity in Human Cells Corn, Benjamin W.; Liber, Howard L.; Little, John B. Radiation Research, Vol. 109, Issue 1 https://doi.org/10.2307/3576871	journal	January 1987
Protection by WR-151327 against Late-Effect Damage from Fission-Spectrum Neutrons Grdina, D. J.; Wright, B. J.; Carnes, B. A. Radiation Research, Vol. 128, Issue 1 https://doi.org/10.2307/3578014	journal	October 1991
Antimutagenic properties of WR 2721 and of a radioprotective mixture, ATP-AET-serotonin, with regard to X ray induced reciprocal translocations in mouse spermatogonia Benova, D. International Journal of Radiation OncologyBiologyPhysics, Vol. 13, Issue 1 https://doi.org/10.1016/0360-3016(87)90268-9	journal	January 1987
Mitochondrial DNA alterations as ageing-associated molecular events Wei, Yau-Huei Mutation Research/DNAging, Vol. 275, Issue 3-6 https://doi.org/10.1016/0921-8734(92)90019-L	journal	September 1992
Models for thiol protection of DNA in cells Held, Kathryn D. Pharmacology & Therapeutics, Vol. 39, Issue 1-3 https://doi.org/10.1016/0163-7258(88)90050-2	journal	January 1988
Chemical Protection against the Long-Term Effects of a Single Whole-Body Exposure of Mice to Ionizing Radiation: I. Life Shortening Maisin, J. R.; Mattelin, G.; Lambiet-Collier, M. Radiation Research, Vol. 71, Issue 1 https://doi.org/10.2307/3574717	journal	July 1977
Antimutagenic Effects of Radioprotector WR-2721 Against Fission-spectrum Neutrons and ⁶⁰ Co γ-rays in Mice Kataoka, Y.; Basic, I.; Perrin, J. International Journal of Radiation Biology, Vol. 61, Issue 3 https://doi.org/10.1080/09553009214551081	journal	January 1992
Oxidative and other DNA damages as the basis of aging: a review Holmes, George E.; Bernstein, Carol; Bernstein, Harris Mutation Research/DNAging, Vol. 275, Issue 3-6 https://doi.org/10.1016/0921-8734(92)90034-M	journal	September 1992
The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation Grdina, David J.; Kataoka, Yasushi; Basic, Ivan Carcinogenesis, Vol. 13, Issue 5 https://doi.org/10.1093/carcin/13.5.811	journal	January 1992
Differential radioprotection of cultured human diploid fibroblasts and fibrosarcoma cells by WR1065 Zhang, Xiafang; Lai, Peter; Taylor, Ybonne International Journal of Radiation OncologyBiologyPhysics, Vol. 21 https://doi.org/10.1016/0360-3016(91)90458-G	journal	January 1991
DNA, mutations and aging Kirkwood, T. B. L. Mutation Research/DNAging, Vol. 219, Issue 1 https://doi.org/10.1016/0921-8734(89)90035-0	journal	January 1989
Protection by WR-2721 of human bone marrow function following irradiation Constine, Louis S.; Zagars, Gunar; Rubin, Philip International Journal of Radiation OncologyBiologyPhysics, Vol. 12, Issue 8 https://doi.org/10.1016/0360-3016(86)90204-X	journal	August 1986
Inhibition of topoisomerase II activity in repair-proficient CHO K1 cells by 2-[(aminopropyl)amino]ethanethiol (WR-1065) Grdina, D. J.; Constantinou, A.; Shigematsu, N. https://doi.org/10.2172/10184593	report	September 1992
Radiation Protectors: the Unexpected Benefits Grdina, David J.; Sigdestad, Curtis P. Drug Metabolism Reviews, Vol. 20, Issue 1 https://doi.org/10.3109/03602538908994143	journal	January 1989
The radioprotector WR1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells Grdina, David J.; Nagy, Biserka; Hill, Colin K. Carcinogenesis, Vol. 6, Issue 6 https://doi.org/10.1093/carcin/6.6.929	journal	January 1985
Protective effects of 2-[(aminopropyl)amino] ethanethiol against bleomycin and nitrogen mustard-induced mutagenicity in V79 cells Nagy, B.; Grdina, D. J. International Journal of Radiation OncologyBiologyPhysics, Vol. 12, Issue 8 https://doi.org/10.1016/0360-3016(86)90197-5	journal	August 1986
Natural antioxidants as inhibitors of oxygen species induced mutagenicity Minnunni, M.; Wolleb, U.; Mueller, O. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 269, Issue 2 https://doi.org/10.1016/0027-5107(92)90200-L	journal	October 1992
Preface: Aging of the 25th chromosome Joenje, Hans Mutation Research/DNAging, Vol. 275, Issue 3-6 https://doi.org/10.1016/0921-8734(92)90015-H	journal	September 1992
Enhancement of Topoisomerase I-Mediated Unwinding of Supercoiled DNA by the Radioprotector WR-33278 Holwitt, Eric A.; Koda, Erik; Swenberg, C. E. Radiation Research, Vol. 124, Issue 1 https://doi.org/10.2307/3577703	journal	October 1990
Protection against Radiation-Induced Mutagenesis in V79 Cells by 2-[(Aminopropyl)amino] Ethanethiol under Conditions of Acute Hypoxia Grdina, David J.; Nagy, Biserka; Hill, Colin K. Radiation Research, Vol. 117, Issue 2 https://doi.org/10.2307/3577326	journal	February 1989
Endogenous glutathione levels modulate the frequency of both spontaneous and long wavelength ultraviolet induced mutations in human cells Applegate, L. A.; Lautier, D.; Frenk, E. Carcinogenesis, Vol. 13, Issue 9 https://doi.org/10.1093/carcin/13.9.1557	journal	January 1992
Pathological Effects of the Radiation Protector WR-151327 in Mice van Beek, M. E. A. B.; Doak, R. L.; Sigdestad, C. P. Radiation Research, Vol. 124, Issue 1 https://doi.org/10.2307/3577698	journal	October 1990
Protection against AZT-induced mutagenesis at the HGPRT locus in a human cell line by WR-151326 Grdina, D. J.; Dale, P.; Weichselbaum, R. International Journal of Radiation OncologyBiologyPhysics, Vol. 22, Issue 4 https://doi.org/10.1016/0360-3016(92)90530-U	journal	January 1992
The inhibitory effect of cysteine on the mutagenic activities of several carcinogens Rosin, Miriam P.; Stich, H. F. Mutation Research/Environmental Mutagenesis and Related Subjects, Vol. 54, Issue 1 https://doi.org/10.1016/0165-1161(78)90137-1	journal	August 1978
Mitochondrial DNA mutation and the ageing process: bioenergy and pharmacological intervention Linnane, Anthony W.; Zhang, Chunfang; Baumer, Alessandra Mutation Research/DNAging, Vol. 275, Issue 3-6 https://doi.org/10.1016/0921-8734(92)90023-I	journal	September 1992
In Vivo Protection by the Aminothiol WR-2721 against Neutron-induced Carcinogenesis Carnes, B. A.; Grdina, D. J. International Journal of Radiation Biology, Vol. 61, Issue 5 https://doi.org/10.1080/09553009214551381	journal	January 1992

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References (26)

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