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Title: Method for protection against genotoxic mutagenesis


A method and pharmaceutical for protecting against mutational damage in mammalian cells, irrespective of the nature of the mutagenic event or source of radiational or chemical insult or the like.

  1. Naperville, IL
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
OSTI Identifier:
Patent Number(s):
US 5869338
Application Number:
Arch Development Corporation (Chicago, IL)
DOE Contract Number:  
Resource Type:
Country of Publication:
United States
method; protection; genotoxic; mutagenesis; pharmaceutical; protecting; mutational; damage; mammalian; cells; irrespective; nature; mutagenic; event; source; radiational; chemical; insult; mammalian cells; chemical insult; mutational damage; mutagenic event; genotoxic mutagenesis; /435/514/

Citation Formats

Grdina, David J. Method for protection against genotoxic mutagenesis. United States: N. p., 1999. Web.
Grdina, David J. Method for protection against genotoxic mutagenesis. United States.
Grdina, David J. Tue . "Method for protection against genotoxic mutagenesis". United States.
title = {Method for protection against genotoxic mutagenesis},
author = {Grdina, David J},
abstractNote = {A method and pharmaceutical for protecting against mutational damage in mammalian cells, irrespective of the nature of the mutagenic event or source of radiational or chemical insult or the like.},
doi = {},
url = {}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1999},
month = {2}


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Works referenced in this record:

Differential radioprotection of cultured human diploid fibroblasts and fibrosarcoma cells by WR1065
journal, January 1991

Protection against Radiation-Induced Mutagenesis in V79 Cells by 2-[(Aminopropyl)amino] Ethanethiol under Conditions of Acute Hypoxia
journal, February 1989

The effect of 2-[(aminopropyl)amino] ethanethiol on fission-neutron-induced DNA damage and repair
journal, January 1989

A Comparison of Radioprotection from Three Neutron Sources and 60 Co by WR-2721 and WR-151327
journal, May 1986

Differential Effects of Radical Scavengers on X-Ray-Induced Mutation and Cytotoxicity in Human Cells
journal, January 1987

Protection against AZT-induced mutagenesis at the HGPRT locus in a human cell line by WR-151326
journal, January 1992

Cell Cycle Redistribution of Cultured Cells After Treatment With Chemical Radiation Protectors
journal, May 1988

The inhibitory effect of cysteine on the mutagenic activities of several carcinogens
journal, August 1978

Chemical protection and cell-cycle effects on radiation-induced mutagenesis
journal, January 1992

Radiation-induced DNA Single-strand Breaks in the Intestinal Mucosal Cells of Mice Treated with the Radioprotectors WR-2721 or 16-16 Dimethyl Prostaglandin E 2
journal, January 1987

Binding of aminoalkylphosphorothioate radioprotective drugs to rodent tissue proteins
journal, June 1990

Radioprotection by wr-151327 against the late normal tissue damage in mouse hind legs from gamma ray radiation
journal, November 1994

Conformational changes in chromatin structure induced by the radioprotective aminothiol, WR 1065
journal, December 1989

2-[(Aminopropyl)amino] Ethanethiol-Mediated Reductions in 60 Co g-Ray and Fission-Spectrum Neutron-Induced Chromosome Damage in V79 Cells
journal, January 1988

The effect of topoisomerase inhibitors on the expression of differentiation markers and cell cycle progression in human K-562 leukemia cells
journal, November 1992

The isoquinoline sulfonamide H7 attenuates radiation-mediated protein kinase C activation and delays the onset of x-ray-induced G2 arrest
journal, January 1992

Effects of growth media on cell cycle progression in CHO cells exposed to the radioprotector WR-1065
journal, November 1992

In Vivo Protection by the Aminothiol WR-2721 against Neutron-induced Carcinogenesis
journal, January 1992

Pathological Effects of the Radiation Protector WR-151327 in Mice
journal, October 1990

DNA, mutations and aging
journal, January 1989

Induction of hprt Mutations in Mice after Exposure to Fission-Spectrum Neutrons or 60 Co Gamma Rays
journal, November 1993

Effects of radioprotectors on DNA damage and repair, proteins, and cell-cycle progression
journal, January 1988

Radiation Protectors: the Unexpected Benefits
journal, January 1989

Natural antioxidants as inhibitors of oxygen species induced mutagenicity
journal, October 1992

Mitochondrial DNA alterations as ageing-associated molecular events
journal, September 1992

Variation in radiation sensitivity during the cell cycle of two human squamous cell carcinomas
journal, April 1991

Oxidative and other DNA damages as the basis of aging: a review
journal, September 1992

Human pharmacokinetics of WR-2721
journal, August 1986

Accumulation of CHO Cells in G 2 Phase Following Exposure to WR-1065
journal, May 1991

Enhancement of Topoisomerase I-Mediated Unwinding of Supercoiled DNA by the Radioprotector WR-33278
journal, October 1990

Protection by WR-2721 and WR-151327 against late effects of gamma rays and neutrons
journal, January 1992

The Increase in Radioresistance of Chinese Hamster Cells Cultured as Spheroids Is Correlated to Changes in Nuclear Morphology
journal, February 1990

Preface: Aging of the 25th chromosome
journal, September 1992

Chemical Protection against the Long-Term Effects of a Single Whole-Body Exposure of Mice to Ionizing Radiation: I. Life Shortening
journal, July 1977

Models for thiol protection of DNA in cells
journal, January 1988

Protection by WR-2721 of human bone marrow function following irradiation
journal, August 1986

The effect of chemical radiation protectors on cell cycle progression after gamma or neutron irradiation
journal, May 1991

Protection by WR-151327 against Late-Effect Damage from Fission-Spectrum Neutrons
journal, October 1991

Association of WR-1065 with CHO AA8 Cells, Nuclei, and Nucleoids
journal, February 1991

Reversion of radiosensitivity in azacytidine-treated xrs5 cells does not result in full radioprotection by WR-1065
journal, January 1992

Phase I Controlled trials of WR-2721 and cyclophosphamide
journal, September 1984

Antimutagenic Effects of Radioprotector WR-2721 Against Fission-spectrum Neutrons and 60 Co γ-rays in Mice
journal, January 1992

Inhibition of Topoisomerase IIα Activity in CHO K1 Cells by 2-[(Aminopropyl)Amino]Ethanethiol (WR-1065)
journal, April 1994

Cellular radiosensitivity in V79 cells is linked to alterations in chromatin structure
journal, November 1990

Radioprotectors in treatment therapy to reduce risk in secondary tumor induction
journal, January 1988

Protection by WR1065 and WR151326 against Fission-Neutron-Induced Mutations at the HGPRT Locus in V79 Cells
journal, March 1989

Mitochondrial DNA mutation and the ageing process: bioenergy and pharmacological intervention
journal, September 1992

Protective effects of 2-[(aminopropyl)amino] ethanethiol against bleomycin and nitrogen mustard-induced mutagenicity in V79 cells
journal, August 1986