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Title: Method for protection against genotoxic mutagenesis

Abstract

A method and pharmaceutical for protecting against genotoxic damage in irradiated cells. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce both free sulfhydryl groups and disulfides.

Inventors:
 [1]
  1. Naperville, IL
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
OSTI Identifier:
870278
Patent Number(s):
US 5488042
Assignee:
Arch Development Corporation (Chicago, IL)
DOE Contract Number:  
W-31109-ENG-38
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
method; protection; genotoxic; mutagenesis; pharmaceutical; protecting; damage; irradiated; cells; reduction; mutations; hypoxanthine-guanine; phosphoribosyl; transferase; locus; accomplished; administering; effective; dose; compound; protected; sulfhydryl; metabolize; vivo; produce; free; disulfides; genotoxic mutagenesis; /514/

Citation Formats

Grdina, David J. Method for protection against genotoxic mutagenesis. United States: N. p., 1996. Web.
Grdina, David J. Method for protection against genotoxic mutagenesis. United States.
Grdina, David J. Mon . "Method for protection against genotoxic mutagenesis". United States. https://www.osti.gov/servlets/purl/870278.
@article{osti_870278,
title = {Method for protection against genotoxic mutagenesis},
author = {Grdina, David J},
abstractNote = {A method and pharmaceutical for protecting against genotoxic damage in irradiated cells. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce both free sulfhydryl groups and disulfides.},
doi = {},
url = {https://www.osti.gov/biblio/870278}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1996},
month = {1}
}

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Works referenced in this record:

Models for thiol protection of DNA in cells
journal, January 1988


Protection by WR-2721 of human bone marrow function following irradiation
journal, August 1986


Protection by WR-151327 against Late-Effect Damage from Fission-Spectrum Neutrons
journal, October 1991


Differential radioprotection of cultured human diploid fibroblasts and fibrosarcoma cells by WR1065
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Protection against Radiation-Induced Mutagenesis in V79 Cells by 2-[(Aminopropyl)amino] Ethanethiol under Conditions of Acute Hypoxia
journal, February 1989


Antimutagenic Effects of Radioprotector WR-2721 Against Fission-spectrum Neutrons and 60 Co γ-rays in Mice
journal, January 1992


Differential Effects of Radical Scavengers on X-Ray-Induced Mutation and Cytotoxicity in Human Cells
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Protection against AZT-induced mutagenesis at the HGPRT locus in a human cell line by WR-151326
journal, January 1992


In Vivo Protection by the Aminothiol WR-2721 against Neutron-induced Carcinogenesis
journal, January 1992


Enhancement of Topoisomerase I-Mediated Unwinding of Supercoiled DNA by the Radioprotector WR-33278
journal, October 1990


Radiation Protectors: the Unexpected Benefits
journal, January 1989


Binding of aminoalkylphosphorothioate radioprotective drugs to rodent tissue proteins
journal, June 1990


Chemical Protection against the Long-Term Effects of a Single Whole-Body Exposure of Mice to Ionizing Radiation: I. Life Shortening
journal, July 1977