Method for protection against genotoxic mutagenesis

Grdina, David J

Method for protection against genotoxic mutagenesis

Patent · Mon Jan 01 04:00:00 EST 1996

OSTI ID:870278

Grdina, David J ^[1]

Naperville, IL

A method and pharmaceutical for protecting against genotoxic damage in irradiated cells. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce both free sulfhydryl groups and disulfides.

View Patent

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL

DOE Contract Number:: W-31109-ENG-38

Assignee:: Arch Development Corporation (Chicago, IL)

Patent Number(s):: US 5488042

OSTI ID:: 870278

Country of Publication:: United States

Language:: English

References (15)

Differential Effects of Radical Scavengers on X-Ray-Induced Mutation and Cytotoxicity in Human Cells Corn, Benjamin W.; Liber, Howard L.; Little, John B. Radiation Research, Vol. 109, Issue 1 https://doi.org/10.2307/3576871	journal	January 1987
Protection by WR-151327 against Late-Effect Damage from Fission-Spectrum Neutrons Grdina, D. J.; Wright, B. J.; Carnes, B. A. Radiation Research, Vol. 128, Issue 1 https://doi.org/10.2307/3578014	journal	October 1991
Antimutagenic properties of WR 2721 and of a radioprotective mixture, ATP-AET-serotonin, with regard to X ray induced reciprocal translocations in mouse spermatogonia Benova, D. International Journal of Radiation OncologyBiologyPhysics, Vol. 13, Issue 1 https://doi.org/10.1016/0360-3016(87)90268-9	journal	January 1987
Models for thiol protection of DNA in cells Held, Kathryn D. Pharmacology & Therapeutics, Vol. 39, Issue 1-3 https://doi.org/10.1016/0163-7258(88)90050-2	journal	January 1988
Chemical Protection against the Long-Term Effects of a Single Whole-Body Exposure of Mice to Ionizing Radiation: I. Life Shortening Maisin, J. R.; Mattelin, G.; Lambiet-Collier, M. Radiation Research, Vol. 71, Issue 1 https://doi.org/10.2307/3574717	journal	July 1977
Antimutagenic Effects of Radioprotector WR-2721 Against Fission-spectrum Neutrons and ⁶⁰ Co γ-rays in Mice Kataoka, Y.; Basic, I.; Perrin, J. International Journal of Radiation Biology, Vol. 61, Issue 3 https://doi.org/10.1080/09553009214551081	journal	January 1992
The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation Grdina, David J.; Kataoka, Yasushi; Basic, Ivan Carcinogenesis, Vol. 13, Issue 5 https://doi.org/10.1093/carcin/13.5.811	journal	January 1992
Differential radioprotection of cultured human diploid fibroblasts and fibrosarcoma cells by WR1065 Zhang, Xiafang; Lai, Peter; Taylor, Ybonne International Journal of Radiation OncologyBiologyPhysics, Vol. 21 https://doi.org/10.1016/0360-3016(91)90458-G	journal	January 1991
Binding of aminoalkylphosphorothioate radioprotective drugs to rodent tissue proteins Livesey, John C.; Grunbaum, Zdenka; Krohn, Kenneth A. Biochemical Pharmacology, Vol. 39, Issue 11 https://doi.org/10.1016/0006-2952(90)90129-9	journal	June 1990
Protection by WR-2721 of human bone marrow function following irradiation Constine, Louis S.; Zagars, Gunar; Rubin, Philip International Journal of Radiation OncologyBiologyPhysics, Vol. 12, Issue 8 https://doi.org/10.1016/0360-3016(86)90204-X	journal	August 1986
Radiation Protectors: the Unexpected Benefits Grdina, David J.; Sigdestad, Curtis P. Drug Metabolism Reviews, Vol. 20, Issue 1 https://doi.org/10.3109/03602538908994143	journal	January 1989
Enhancement of Topoisomerase I-Mediated Unwinding of Supercoiled DNA by the Radioprotector WR-33278 Holwitt, Eric A.; Koda, Erik; Swenberg, C. E. Radiation Research, Vol. 124, Issue 1 https://doi.org/10.2307/3577703	journal	October 1990
Protection against Radiation-Induced Mutagenesis in V79 Cells by 2-[(Aminopropyl)amino] Ethanethiol under Conditions of Acute Hypoxia Grdina, David J.; Nagy, Biserka; Hill, Colin K. Radiation Research, Vol. 117, Issue 2 https://doi.org/10.2307/3577326	journal	February 1989
Protection against AZT-induced mutagenesis at the HGPRT locus in a human cell line by WR-151326 Grdina, D. J.; Dale, P.; Weichselbaum, R. International Journal of Radiation OncologyBiologyPhysics, Vol. 22, Issue 4 https://doi.org/10.1016/0360-3016(92)90530-U	journal	January 1992
In Vivo Protection by the Aminothiol WR-2721 against Neutron-induced Carcinogenesis Carnes, B. A.; Grdina, D. J. International Journal of Radiation Biology, Vol. 61, Issue 5 https://doi.org/10.1080/09553009214551381	journal	January 1992

Similar Records

Method for protection against genotoxic mutagenesis

Patent · Mon Jan 29 23:00:00 EST 1996 · OSTI ID:187071

Application of an in vivo mutagenesis system to assess aminothiol effects on neutron-induced genotoxic damage in mouse spleenocytes

Conference · Sat Dec 31 23:00:00 EST 1988 · OSTI ID:7244335

Method for protection against genotoxic mutagenesis

Patent · Sun Dec 31 23:00:00 EST 1995 · OSTI ID:870650

Related Subjects

/514/
accomplished
administering
cells
compound
damage
disulfides
dose
effective
free
genotoxic
genotoxic mutagenesis
hypoxanthine-guanine
irradiated
locus
metabolize
method
mutagenesis
mutations
pharmaceutical
phosphoribosyl
produce
protected
protecting
protection
reduction
sulfhydryl
transferase
vivo

Method for protection against genotoxic mutagenesis

Citation Formats

References (15)

Similar Records

Related Subjects