Method for protection against genotoxic mutagenesis
Patent
·
OSTI ID:187071
A method and pharmaceutical for protecting against genotoxic damage in irradiated cells are disclosed. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce both free sulfhydryl groups and disulfides. 10 figs.
- Research Organization:
- University of Chicago
- DOE Contract Number:
- W-31109-ENG-38
- Assignee:
- Arch Development Corp., Chicago, IL (United States)
- Patent Number(s):
- US 5,488,042/A/
- Application Number:
- PAN: 7-851,210
- OSTI ID:
- 187071
- Country of Publication:
- United States
- Language:
- English
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