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Combined electrophoresis-electrospray interface and method

Patent ·
OSTI ID:869923
 [1];  [1];  [1]
  1. Richland, WA
+ Show Author Affiliations

An improvement to the system and method for analyzing molecular constituents of a composition sample that comprises improvements to an electrospray ionization source for interfacing to mass spectrometers and other detection devices. The improvement consists of establishing a unique electrical circuit pattern and nozzle configuration, a metallic coated and conical shaped capillary outlet, coupled with sizing of the capillary to obtain maximum sensitivity.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA
DOE Contract Number:
AC06-76RL01830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
US 5423964
OSTI ID:
869923
Country of Publication:
United States
Language:
English

References (6)

Improved electrospray ionization interface for capillary zone electrophoresis-mass spectrometry journal September 1988
Capillary Electrophoresis/Mass Spectrometry journal July 1993
Attomole level capillary electrophoresis-mass spectrometric protein analysis using 5 .mu.m i.d. capillaries journal December 1992
Use of small-diameter capillaries for increasing peptide and protein detection sensitivity in capillary electrophoresis-mass spectrometry journal January 1993
Instrumentation for high-performance capillary electrophoresis—mass spectrometry journal October 1991
Sheathless capillary electrophoresis-electrospray ionization mass spectrometry using 10 μm I.D. capillaries: Analyses of tryptic digests of cytochrome c journal January 1994

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Related Subjects

/204/250/
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mass
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