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Title: Combined electrophoresis-electrospray interface and method

Patent ·
OSTI ID:869923
 [1];  [1];  [1]
  1. Richland, WA
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An improvement to the system and method for analyzing molecular constituents of a composition sample that comprises improvements to an electrospray ionization source for interfacing to mass spectrometers and other detection devices. The improvement consists of establishing a unique electrical circuit pattern and nozzle configuration, a metallic coated and conical shaped capillary outlet, coupled with sizing of the capillary to obtain maximum sensitivity.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
DOE Contract Number:
AC06-76RL01830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
US 5423964
OSTI ID:
869923
Country of Publication:
United States
Language:
English

References (6)

Improved electrospray ionization interface for capillary zone electrophoresis-mass spectrometry journal September 1988
Use of small-diameter capillaries for increasing peptide and protein detection sensitivity in capillary electrophoresis-mass spectrometry journal January 1993
Capillary Electrophoresis/Mass Spectrometry journal July 1993
Attomole level capillary electrophoresis-mass spectrometric protein analysis using 5 .mu.m i.d. capillaries journal December 1992
Instrumentation for high-performance capillary electrophoresis—mass spectrometry journal October 1991
Sheathless capillary electrophoresis-electrospray ionization mass spectrometry using 10 μm I.D. capillaries: Analyses of tryptic digests of cytochrome c journal January 1994

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combined
electrophoresis-electrospray
interface
method
improvement
analyzing
molecular
constituents
composition
sample
comprises
improvements
electrospray
ionization
source
interfacing
mass
spectrometers
detection
devices
consists
establishing
unique
electrical
circuit
pattern
nozzle
configuration
metallic
coated
conical
shaped
capillary
outlet
coupled
sizing
obtain
maximum
sensitivity
molecular constituents
electrospray ionization
detection device
mass spectrometers
mass spectrometer
electrical circuit
circuit pattern
ionization source
shaped capillary
metallic coated
combined electrophoresis-electrospray
detection devices
composition sample
analyzing molecular
electrophoresis-electrospray interface
improvement consists
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